T-cell monoclonality in Hodgkin's lymphoma. Composite lymphoma or Hodgkin's lymphoma with reactive T-cell monoclonal population

Isidro Machado, Francesco Mecci, María Dolores Linares Latorre, Carmen Illueca, Victor Través, Isabel Picón Roig, Pablo Lorente Alegre, Zaida García-Casado, Beatriz Llombart, Stefano Pileri

Research output: Contribution to journalArticle

Abstract

Introduction: The diagnosis and management of malignant lymphoma should be based on clinical, morphological, immunohistochemical and molecular information. Particularly in cases with morphological and/or immunohistochemistry overlapping, molecular biology provides important diagnostic clues. Material and methods: A 72 year-old male with mycosis fungoides, pancitopenia and hepatosplenomagly without lymph node enlargement, underwent both hepatic and bone marrow biopsies and histopathological, immunohistochemical and molecular studies were performed. Results: The bone marrow and hepatic biopsies showed two different populations, one composed of large cells including typical Reed-Sternberg cells and their variant, with expression of CD30, CD15, MUM1 and EBV. The other was more extensive and revealed polymorphic medium to small cells with convoluted nuclei positive for CD3, CD4, CD2, CD7. Clonal T cell receptor gamma and monoclonal immunoglobulin H gene were detected in the bone marrow infiltration. Conclusion: The interpretation of the molecular results in the diagnosis of lymphoma should be strictly correlated with the clinical evolution and the morphological and immunohistochemical findings.

Translated title of the contributionT-cell monoclonality in Hodgkin's lymphoma. Composite lymphoma or Hodgkin's lymphoma with reactive T-cell monoclonal population
Original languageSpanish
Pages (from-to)186-192
Number of pages7
JournalRevista Espanola de Patologia
Volume45
Issue number3
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Composite Lymphoma
Hodgkin Disease
Bone Marrow
T-Lymphocytes
Lymphoma
Population
Reed-Sternberg Cells
Biopsy
Mycosis Fungoides
Immunoglobulin Genes
Liver
T-Cell Antigen Receptor
Human Herpesvirus 4
Molecular Biology
Lymph Nodes
Immunohistochemistry

Keywords

  • Composite lymphoma
  • Hodgkin's lymphoma
  • Linfoma compuesto
  • Linfoma de Hodgkin
  • Monoclonalidad T y B
  • T and B monoclonality

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Monoclonalidad T en paciente con linfoma de Hodgkin. ¿Linfoma compuesto o linfoma de Hodgkin con población T monoclonal reactiva? / Machado, Isidro; Mecci, Francesco; Linares Latorre, María Dolores; Illueca, Carmen; Través, Victor; Picón Roig, Isabel; Lorente Alegre, Pablo; García-Casado, Zaida; Llombart, Beatriz; Pileri, Stefano.

In: Revista Espanola de Patologia, Vol. 45, No. 3, 07.2012, p. 186-192.

Research output: Contribution to journalArticle

Machado, I, Mecci, F, Linares Latorre, MD, Illueca, C, Través, V, Picón Roig, I, Lorente Alegre, P, García-Casado, Z, Llombart, B & Pileri, S 2012, 'Monoclonalidad T en paciente con linfoma de Hodgkin. ¿Linfoma compuesto o linfoma de Hodgkin con población T monoclonal reactiva?' Revista Espanola de Patologia, vol. 45, no. 3, pp. 186-192. https://doi.org/10.1016/j.patol.2011.11.006
Machado, Isidro ; Mecci, Francesco ; Linares Latorre, María Dolores ; Illueca, Carmen ; Través, Victor ; Picón Roig, Isabel ; Lorente Alegre, Pablo ; García-Casado, Zaida ; Llombart, Beatriz ; Pileri, Stefano. / Monoclonalidad T en paciente con linfoma de Hodgkin. ¿Linfoma compuesto o linfoma de Hodgkin con población T monoclonal reactiva?. In: Revista Espanola de Patologia. 2012 ; Vol. 45, No. 3. pp. 186-192.
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