Abstract
Introduction: The diagnosis and management of malignant lymphoma should be based on clinical, morphological, immunohistochemical and molecular information. Particularly in cases with morphological and/or immunohistochemistry overlapping, molecular biology provides important diagnostic clues. Material and methods: A 72 year-old male with mycosis fungoides, pancitopenia and hepatosplenomagly without lymph node enlargement, underwent both hepatic and bone marrow biopsies and histopathological, immunohistochemical and molecular studies were performed. Results: The bone marrow and hepatic biopsies showed two different populations, one composed of large cells including typical Reed-Sternberg cells and their variant, with expression of CD30, CD15, MUM1 and EBV. The other was more extensive and revealed polymorphic medium to small cells with convoluted nuclei positive for CD3, CD4, CD2, CD7. Clonal T cell receptor gamma and monoclonal immunoglobulin H gene were detected in the bone marrow infiltration. Conclusion: The interpretation of the molecular results in the diagnosis of lymphoma should be strictly correlated with the clinical evolution and the morphological and immunohistochemical findings.
| Translated title of the contribution | T-cell monoclonality in Hodgkin's lymphoma. Composite lymphoma or Hodgkin's lymphoma with reactive T-cell monoclonal population |
|---|---|
| Language | Spanish |
| Pages | 186-192 |
| Number of pages | 7 |
| Journal | Revista Espanola de Patologia |
| Volume | 45 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 2012 |
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Keywords
- Composite lymphoma
- Hodgkin's lymphoma
- Linfoma compuesto
- Linfoma de Hodgkin
- Monoclonalidad T y B
- T and B monoclonality
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Monoclonalidad T en paciente con linfoma de Hodgkin. ¿Linfoma compuesto o linfoma de Hodgkin con población T monoclonal reactiva? / Machado, Isidro; Mecci, Francesco; Linares Latorre, María Dolores; Illueca, Carmen; Través, Victor; Picón Roig, Isabel; Lorente Alegre, Pablo; García-Casado, Zaida; Llombart, Beatriz; Pileri, Stefano.
In: Revista Espanola de Patologia, Vol. 45, No. 3, 07.2012, p. 186-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Monoclonalidad T en paciente con linfoma de Hodgkin. ¿Linfoma compuesto o linfoma de Hodgkin con población T monoclonal reactiva?
AU - Machado, Isidro
AU - Mecci, Francesco
AU - Linares Latorre, María Dolores
AU - Illueca, Carmen
AU - Través, Victor
AU - Picón Roig, Isabel
AU - Lorente Alegre, Pablo
AU - García-Casado, Zaida
AU - Llombart, Beatriz
AU - Pileri, Stefano
PY - 2012/7
Y1 - 2012/7
N2 - Introduction: The diagnosis and management of malignant lymphoma should be based on clinical, morphological, immunohistochemical and molecular information. Particularly in cases with morphological and/or immunohistochemistry overlapping, molecular biology provides important diagnostic clues. Material and methods: A 72 year-old male with mycosis fungoides, pancitopenia and hepatosplenomagly without lymph node enlargement, underwent both hepatic and bone marrow biopsies and histopathological, immunohistochemical and molecular studies were performed. Results: The bone marrow and hepatic biopsies showed two different populations, one composed of large cells including typical Reed-Sternberg cells and their variant, with expression of CD30, CD15, MUM1 and EBV. The other was more extensive and revealed polymorphic medium to small cells with convoluted nuclei positive for CD3, CD4, CD2, CD7. Clonal T cell receptor gamma and monoclonal immunoglobulin H gene were detected in the bone marrow infiltration. Conclusion: The interpretation of the molecular results in the diagnosis of lymphoma should be strictly correlated with the clinical evolution and the morphological and immunohistochemical findings.
AB - Introduction: The diagnosis and management of malignant lymphoma should be based on clinical, morphological, immunohistochemical and molecular information. Particularly in cases with morphological and/or immunohistochemistry overlapping, molecular biology provides important diagnostic clues. Material and methods: A 72 year-old male with mycosis fungoides, pancitopenia and hepatosplenomagly without lymph node enlargement, underwent both hepatic and bone marrow biopsies and histopathological, immunohistochemical and molecular studies were performed. Results: The bone marrow and hepatic biopsies showed two different populations, one composed of large cells including typical Reed-Sternberg cells and their variant, with expression of CD30, CD15, MUM1 and EBV. The other was more extensive and revealed polymorphic medium to small cells with convoluted nuclei positive for CD3, CD4, CD2, CD7. Clonal T cell receptor gamma and monoclonal immunoglobulin H gene were detected in the bone marrow infiltration. Conclusion: The interpretation of the molecular results in the diagnosis of lymphoma should be strictly correlated with the clinical evolution and the morphological and immunohistochemical findings.
KW - Composite lymphoma
KW - Hodgkin's lymphoma
KW - Linfoma compuesto
KW - Linfoma de Hodgkin
KW - Monoclonalidad T y B
KW - T and B monoclonality
UR - http://www.scopus.com/inward/record.url?scp=84864758006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864758006&partnerID=8YFLogxK
U2 - 10.1016/j.patol.2011.11.006
DO - 10.1016/j.patol.2011.11.006
M3 - Articolo
VL - 45
SP - 186
EP - 192
JO - Revista Espanola de Patologia
T2 - Revista Espanola de Patologia
JF - Revista Espanola de Patologia
SN - 1699-8855
IS - 3
ER -