Twelve cases of Tγ LPD (lymphoproliferative disorders of Fcγ receptor-bearing T cells) involving an expansion of large granular lymphocyte/natural killer (LGL/NK) cells were investigated for the expression of LGL/NK-associated markers and for Tβ gene rearrangement. All the cases selected were classified as Tγ LPD on the basis of morphology, function, and phenotype of the circulating cells. 10 to 12 cases displayed clonal rearrangements of the Tβ locus and expression of the T3 antigen, whereas the 2 remaining cases displayed the germline configuration of the Tβ gene and no expression of the T3 antigen. T8, Mol, B73.1, and N901 antigens were variably expressed among both Tβ+T3+ and Tβ-T3-Tγ LPD cases. We suggest that individual Tγ LPD cases represent the clonal expansion of cells frozen at different stages of differentiation/activation within an individual hematopoietic LGL/NK lineage.
|Number of pages||7|
|Journal||Journal of Experimental Medicine|
|Publication status||Published - 1985|
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