T cell receptor β chain gene rearrangements in lymphoproliferative disorders of large granular lymphocytes/natural killer cells

A. Rambaldi, P. G. Pelicci, P. Allavena, D. M. Knowles, S. Rossini, R. Bassan, T. Barbui, R. Dalla-Favera, A. Mantovani

Research output: Contribution to journalArticle

Abstract

Twelve cases of Tγ LPD (lymphoproliferative disorders of Fcγ receptor-bearing T cells) involving an expansion of large granular lymphocyte/natural killer (LGL/NK) cells were investigated for the expression of LGL/NK-associated markers and for Tβ gene rearrangement. All the cases selected were classified as Tγ LPD on the basis of morphology, function, and phenotype of the circulating cells. 10 to 12 cases displayed clonal rearrangements of the Tβ locus and expression of the T3 antigen, whereas the 2 remaining cases displayed the germline configuration of the Tβ gene and no expression of the T3 antigen. T8, Mol, B73.1, and N901 antigens were variably expressed among both Tβ+T3+ and Tβ-T3-Tγ LPD cases. We suggest that individual Tγ LPD cases represent the clonal expansion of cells frozen at different stages of differentiation/activation within an individual hematopoietic LGL/NK lineage.

Original languageEnglish
Pages (from-to)2156-2162
Number of pages7
JournalJournal of Experimental Medicine
Volume162
Issue number6
Publication statusPublished - 1985

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T-Cell Receptor Genes
Lymphoproliferative Disorders
Gene Rearrangement
Natural Killer Cells
CD3 Antigens
Lymphocytes
Fc Receptors
T-Lymphocytes
Phenotype
Gene Expression
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

T cell receptor β chain gene rearrangements in lymphoproliferative disorders of large granular lymphocytes/natural killer cells. / Rambaldi, A.; Pelicci, P. G.; Allavena, P.; Knowles, D. M.; Rossini, S.; Bassan, R.; Barbui, T.; Dalla-Favera, R.; Mantovani, A.

In: Journal of Experimental Medicine, Vol. 162, No. 6, 1985, p. 2156-2162.

Research output: Contribution to journalArticle

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AU - Rambaldi, A.

AU - Pelicci, P. G.

AU - Allavena, P.

AU - Knowles, D. M.

AU - Rossini, S.

AU - Bassan, R.

AU - Barbui, T.

AU - Dalla-Favera, R.

AU - Mantovani, A.

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AB - Twelve cases of Tγ LPD (lymphoproliferative disorders of Fcγ receptor-bearing T cells) involving an expansion of large granular lymphocyte/natural killer (LGL/NK) cells were investigated for the expression of LGL/NK-associated markers and for Tβ gene rearrangement. All the cases selected were classified as Tγ LPD on the basis of morphology, function, and phenotype of the circulating cells. 10 to 12 cases displayed clonal rearrangements of the Tβ locus and expression of the T3 antigen, whereas the 2 remaining cases displayed the germline configuration of the Tβ gene and no expression of the T3 antigen. T8, Mol, B73.1, and N901 antigens were variably expressed among both Tβ+T3+ and Tβ-T3-Tγ LPD cases. We suggest that individual Tγ LPD cases represent the clonal expansion of cells frozen at different stages of differentiation/activation within an individual hematopoietic LGL/NK lineage.

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