T cell response to myelin basic protein before and after treatment with interferon beta in multiple sclerosis

Giovanni Ristori, Chiara Montesperelli, Claudio Gasperini, Luca Battistini, Giovanna Borsellino, Carla Buttinelli, Stefania Cannoni, Alessia Perna, Carlo Pozzilli, Marco Salvetti

Research output: Contribution to journalArticle

Abstract

Studies on the in vivo effects of interferon-β (IFNβ) therapy on autoreactive T cells have never been carried out in multiple sclerosis (MS). We investigated the T cell response to myelin basic protein (MBP), before and after IFN-β therapy, raising MBP-specific T cell lines (TCL) from the peripheral blood of six MS patients with a satisfactory response to the treatment. IFNβ did not affect the relative frequency and epitope specificity of the TCL. After IFNβ therapy, the production of interleukin-4 was decreased in MBP-stimulated TCL while the secretion of interferon-γ was increased in unstimulated TCL. Interleukin-10 and tumor necrosis factor-α did not show significant variations. This finding supports recent suggestions about the complexity of the T helper 1/T helper 2 paradigm in MS and other organ-specific autoimmune diseases. In fact, the beneficial effects of IFNβ do not exclude an immunostimulatory action that may involve potentially autoreactive T cells. This has implications for future treatment options, including combination therapies.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalJournal of Neuroimmunology
Volume99
Issue number1
DOIs
Publication statusPublished - Sep 1 1999

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Keywords

  • Interferon beta
  • Multiple sclerosis
  • Myelin basic protein
  • T lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Ristori, G., Montesperelli, C., Gasperini, C., Battistini, L., Borsellino, G., Buttinelli, C., Cannoni, S., Perna, A., Pozzilli, C., & Salvetti, M. (1999). T cell response to myelin basic protein before and after treatment with interferon beta in multiple sclerosis. Journal of Neuroimmunology, 99(1), 91-96. https://doi.org/10.1016/S0165-5728(99)00107-1