T cell selection and differentiation in AIDS disease: the model of HIV-discordant monozygotic twins.

C. Agrati, C. Gioia, F. Soldani, F. Martini, A. Antinori, F. Poccia

Research output: Contribution to journalArticlepeer-review

Abstract

The model of monozygotic twins has been repeatedly studied to control the genetic and age-specific effects on HIV disease. Focusing on this natural model, the expression of CD27/CD45RA differentiation markers and the distribution of the Vbeta TCR repertoire was analyzed on CD4+ and CD8+ T cells. In our HIV-discordant monozygotic twins, a significant reduction of naive T cells and a parallel accumulation of effector/memory T cells was induced by HIV infection, as well as a skewing of T cell repertoire evidenced by VbetaTCR analysis. The block of HIV replication by highly active antiretroviral therapy (HAART) restored most of the T cell maturation and selection process, with some exception among CTL differentiation and repertoire. Altogether, the model of HIV-discordant monozygotic twins is a valuable tool showing that HAART is not able to completely restore the CTL profile.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume20
Issue number1-2
Publication statusPublished - Jan 2006

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

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