T cell subpopulations after allogeneic bone marrow transplantation.

A. Bacigalupo, M. C. Mingari, L. Moretta, M. T. van Lint, G. Piaggio, M. R. Raffo, M. Podesta, A. M. Marmont

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

T-cell subpopulations were studied in six patients after allogeneic bone marrow transplantation for aplastic anemia and acute leukaemia, by means of receptors for IgG (TG-cells) and IgM (TM-cells). Significant modifications of TM-TG levels were found: a 2 to 10 fold increase of TG cells and a 2 to 10 fold decrease of TM cells from pre-transplant levels could be observed. The TM-TG imbalance appeared together with the clinical signs of GVHD: the level of TM-depression (but not the level of TG increase) correlated with the severity of GVHD. The TM-TG modifications were observed as long as 3 years after transplantation, also in the absence of signs of GVHD. In addition, all six patients were found to have severely impaired pokeweed-induced B-cell differentiation. The clinical implications and the possible lack of T-helper activity are discussed.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalHamatologie und Bluttransfusion
Volume25
Publication statusPublished - 1980

Fingerprint

Homologous Transplantation
Bone Marrow Transplantation
T-Lymphocytes
Phytolacca americana
IgG Receptors
Aplastic Anemia
Immunoglobulin M
Cell Differentiation
Leukemia
B-Lymphocytes
Transplantation
Transplants

ASJC Scopus subject areas

  • Medicine(all)

Cite this

T cell subpopulations after allogeneic bone marrow transplantation. / Bacigalupo, A.; Mingari, M. C.; Moretta, L.; van Lint, M. T.; Piaggio, G.; Raffo, M. R.; Podesta, M.; Marmont, A. M.

In: Hamatologie und Bluttransfusion, Vol. 25, 1980, p. 135-140.

Research output: Contribution to journalArticle

@article{a518c3f120ff4c1ead4742d9ab5507e4,
title = "T cell subpopulations after allogeneic bone marrow transplantation.",
abstract = "T-cell subpopulations were studied in six patients after allogeneic bone marrow transplantation for aplastic anemia and acute leukaemia, by means of receptors for IgG (TG-cells) and IgM (TM-cells). Significant modifications of TM-TG levels were found: a 2 to 10 fold increase of TG cells and a 2 to 10 fold decrease of TM cells from pre-transplant levels could be observed. The TM-TG imbalance appeared together with the clinical signs of GVHD: the level of TM-depression (but not the level of TG increase) correlated with the severity of GVHD. The TM-TG modifications were observed as long as 3 years after transplantation, also in the absence of signs of GVHD. In addition, all six patients were found to have severely impaired pokeweed-induced B-cell differentiation. The clinical implications and the possible lack of T-helper activity are discussed.",
author = "A. Bacigalupo and Mingari, {M. C.} and L. Moretta and {van Lint}, {M. T.} and G. Piaggio and Raffo, {M. R.} and M. Podesta and Marmont, {A. M.}",
year = "1980",
language = "English",
volume = "25",
pages = "135--140",
journal = "Hamatologie und Bluttransfusion",
issn = "0440-0607",

}

TY - JOUR

T1 - T cell subpopulations after allogeneic bone marrow transplantation.

AU - Bacigalupo, A.

AU - Mingari, M. C.

AU - Moretta, L.

AU - van Lint, M. T.

AU - Piaggio, G.

AU - Raffo, M. R.

AU - Podesta, M.

AU - Marmont, A. M.

PY - 1980

Y1 - 1980

N2 - T-cell subpopulations were studied in six patients after allogeneic bone marrow transplantation for aplastic anemia and acute leukaemia, by means of receptors for IgG (TG-cells) and IgM (TM-cells). Significant modifications of TM-TG levels were found: a 2 to 10 fold increase of TG cells and a 2 to 10 fold decrease of TM cells from pre-transplant levels could be observed. The TM-TG imbalance appeared together with the clinical signs of GVHD: the level of TM-depression (but not the level of TG increase) correlated with the severity of GVHD. The TM-TG modifications were observed as long as 3 years after transplantation, also in the absence of signs of GVHD. In addition, all six patients were found to have severely impaired pokeweed-induced B-cell differentiation. The clinical implications and the possible lack of T-helper activity are discussed.

AB - T-cell subpopulations were studied in six patients after allogeneic bone marrow transplantation for aplastic anemia and acute leukaemia, by means of receptors for IgG (TG-cells) and IgM (TM-cells). Significant modifications of TM-TG levels were found: a 2 to 10 fold increase of TG cells and a 2 to 10 fold decrease of TM cells from pre-transplant levels could be observed. The TM-TG imbalance appeared together with the clinical signs of GVHD: the level of TM-depression (but not the level of TG increase) correlated with the severity of GVHD. The TM-TG modifications were observed as long as 3 years after transplantation, also in the absence of signs of GVHD. In addition, all six patients were found to have severely impaired pokeweed-induced B-cell differentiation. The clinical implications and the possible lack of T-helper activity are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0019098865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019098865&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 135

EP - 140

JO - Hamatologie und Bluttransfusion

JF - Hamatologie und Bluttransfusion

SN - 0440-0607

ER -