T-cell subsets and serum immunoglobulin levels in infants born to HIV-seropositive mothers: A longitudinal evaluation

Antonella D Arminio Monforte, Roberto Novati, Massimo Galli, Paola Marchisio, Emilia Massironi, Raffaella Tornaghi, Alberto Saracco, Nicola Principi, Mauro Moroni

Research output: Contribution to journalArticle

Abstract

T-lymphocyte subsets and serum immunoglobulins were assayed in 27 neonates and 12 infants younger than 6 months, all born to HIV-seropositive mothers. No differences in T-lymphocyte subsets between the 27 seropositive and 34 seronegative infants were found at birth. Twelve seroreverted and 14 infected children were followed. CD4+ cell counts were significantly lower in the latter at 3 and 24 months of age. Serum immunoglobulin levels and CD8+ percentages became higher in the infected group, starting from the sixth month, while CD4+ percentages and CD4+/CD8+ ratios became lower, starting from the twelfth month.

Original languageEnglish
Pages (from-to)1141-1144
Number of pages4
JournalAIDS (London, England)
Volume4
Issue number11
Publication statusPublished - Nov 1990

Keywords

  • HIV seroreverted infants
  • HIV-infected infants
  • Serum immunoglobulin levels
  • T-lymphocyte subsets

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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