T-cell subsets in Hodgkin's disease: A study of peripheral blood, spleen and involved tissue

M. Gobbi, F. Lauria, D. Raspadori

Research output: Contribution to journalArticlepeer-review

Abstract

T-cell subsets of peripheral blood, spleen and involved tissues were studied in 25 patients with Hodgkin's Disease (HD) using anti T-lymphocytes monoclonal antibodies of the OKT series (Ortho). Total T-lymphocytes (OKT3+ cells) as well as lymphocytes with helper/inducer phenotype (OKT4+ cells) were found slightly reduced in peripheral blood of HD patients. On the contrary, high percentages of OKT3+ OKT4+ cells were found in the neoplastic tissue and in the only spleen which was involved by some neoplastic nodules. These results are consistent with an accumulation of helper-inducer cells in involved lymphnodes and spleen. Functional studies of the OKT4+ will possibly clarify mechanisms related to the disease pathogenesis.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalJournal of Experimental and Clinical Cancer Research
Volume1
Issue number1
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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