T-cell subsets of peripheral blood, spleen and involved tissues were studied in 25 patients with Hodgkin's Disease (HD) using anti T-lymphocytes monoclonal antibodies of the OKT series (Ortho). Total T-lymphocytes (OKT3+ cells) as well as lymphocytes with helper/inducer phenotype (OKT4+ cells) were found slightly reduced in peripheral blood of HD patients. On the contrary, high percentages of OKT3+ OKT4+ cells were found in the neoplastic tissue and in the only spleen which was involved by some neoplastic nodules. These results are consistent with an accumulation of helper-inducer cells in involved lymphnodes and spleen. Functional studies of the OKT4+ will possibly clarify mechanisms related to the disease pathogenesis.
|Number of pages||6|
|Journal||Journal of Experimental and Clinical Cancer Research|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Cancer Research