T-cell subsets in multiple sclerosis: Relationships between peripheral blood and cerebrospinal fluid

M. Zaffaroni, D. Caputo, A. Ghezzi, C. L. Cazzullo

Research output: Contribution to journalArticlepeer-review

Abstract

We contemporarily studied cerebrospinal fluid (CSF) and peripheral blood (PB) T-cell subsets, defined by monoclonal antibodies, in 29 patients with multiple sclerosis (MS) and 10 patients with other neurological diseases (OND). All subjects showed a clear-cut prevalence of CSF T-cells. Similarly, T-helper and T-suppressor subsets tended to show higher percentages in CSF in almost all subjects except relapsing MS, who were characterized by low percentages of T-suppressors in PB and even much lower percentages in CSF. Helper/suppressor ratios were found to be almost similar in the two body compartments of OND patients, lower in CSF than in PB of chronic progressive MS, always higher in CSF than in PB of relapsing MS. MS patients in remission showed both patterns of progressive MS and OND patients. Our results demonstrate that the loss of PB T-suppressor in relapsing MS is not due to a migration of such cells into CSF. Furthermore, regarding T-lymphocyte subsets, a typical CSF/PB pattern characterizes relapsing MS from other patients.

Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalActa Neurologica Scandinavica
Volume71
Issue number3
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'T-cell subsets in multiple sclerosis: Relationships between peripheral blood and cerebrospinal fluid'. Together they form a unique fingerprint.

Cite this