Abstract
The supernatant of T(E)+ lymphocytes isolated by density gradient from a lympho-epithelial thymoma contained a biochemical variant of T cell growth factor (IL-2). This protein showed two peaks with an apparent molecular weight of 18 and 28 kd by Sephadex G 100 chromatography. Further purification was achieved by DEAE Sephacel and CM Sepharose ion-exchange chromatography. By isoelectric focusing the isoelectric point was found to differ from that of normal IL-2. Based on these results, the IL-2 variant appears to be a new kind of lymphokine distinguishable from normal IL-2 and similar to a TCGF (L-TCGF peak II) purified from the malignant T cell clone HUT 102.
| Original language | English |
|---|---|
| Pages (from-to) | 251-263 |
| Number of pages | 13 |
| Journal | Lymphokine Research |
| Volume | 4 |
| Issue number | 3 |
| Publication status | Published - 1985 |
ASJC Scopus subject areas
- Immunology
- Hematology
Fingerprint Dive into the research topics of 'T cells from lymphoepithelial thymoma produce a biochemical variant of IL-2'. Together they form a unique fingerprint.
Cite this
Cornaglia-Ferraris, P., & Ponzoni, M. (1985). T cells from lymphoepithelial thymoma produce a biochemical variant of IL-2. Lymphokine Research, 4(3), 251-263.