T cells, mast cells and microvascular density in diffuse large B cell lymphoma

Christian Marinaccio; Giuseppe Ingravallo; Francesco Gaudio; Tommasina Perrone; Simona Ruggieri; Giuseppina Opinto; Beatrice Nico; Eugenio Maiorano; Giorgina Specchia; Domenico Ribatti

doi:10.1007/s10238-015-0354-5

T cells, mast cells and microvascular density in diffuse large B cell lymphoma

Christian Marinaccio, Giuseppe Ingravallo, Francesco Gaudio, Tommasina Perrone, Simona Ruggieri, Giuseppina Opinto, Beatrice Nico, Eugenio Maiorano, Giorgina Specchia, Domenico Ribatti

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammatory infiltrate, T cells and mast cells have been demonstrated to be correlated with tumor angiogenesis. In this report, we have investigated CD3 and tryptase expression and their relationship with microvascular density (MVD) in DLBCL patients. Moreover, we determined the significance of CD3 expression in bulky and non-bulky disease. CD3 expression was significantly lower in bulky disease patients when compared to non-bulky ones. CD3 showed a positive correlation with tryptase and MVD, while multiple regression analysis efficaciously predicted MVD depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in DLBCL patients.

Original language	English
Journal	Clinical and Experimental Medicine
DOIs	https://doi.org/10.1007/s10238-015-0354-5
Publication status	Accepted/In press - May 10 2015

Keywords

Angiogenesis
Diffuse large B cell lymphoma
Mast cells
Microvascular density
T cells

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/s10238-015-0354-5

Fingerprint Dive into the research topics of 'T cells, mast cells and microvascular density in diffuse large B cell lymphoma'. Together they form a unique fingerprint.

Cite this

T cells, mast cells and microvascular density in diffuse large B cell lymphoma. / Marinaccio, Christian; Ingravallo, Giuseppe; Gaudio, Francesco; Perrone, Tommasina; Ruggieri, Simona; Opinto, Giuseppina; Nico, Beatrice; Maiorano, Eugenio; Specchia, Giorgina; Ribatti, Domenico.

In: Clinical and Experimental Medicine, 10.05.2015.

Research output: Contribution to journal › Article › peer-review

@article{6e935a96adec41edbd2cc4191e36e51e,

title = "T cells, mast cells and microvascular density in diffuse large B cell lymphoma",

abstract = "Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammatory infiltrate, T cells and mast cells have been demonstrated to be correlated with tumor angiogenesis. In this report, we have investigated CD3 and tryptase expression and their relationship with microvascular density (MVD) in DLBCL patients. Moreover, we determined the significance of CD3 expression in bulky and non-bulky disease. CD3 expression was significantly lower in bulky disease patients when compared to non-bulky ones. CD3 showed a positive correlation with tryptase and MVD, while multiple regression analysis efficaciously predicted MVD depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in DLBCL patients.",

keywords = "Angiogenesis, Diffuse large B cell lymphoma, Mast cells, Microvascular density, T cells",

author = "Christian Marinaccio and Giuseppe Ingravallo and Francesco Gaudio and Tommasina Perrone and Simona Ruggieri and Giuseppina Opinto and Beatrice Nico and Eugenio Maiorano and Giorgina Specchia and Domenico Ribatti",

year = "2015",

month = may,

day = "10",

doi = "10.1007/s10238-015-0354-5",

language = "English",

journal = "Zeitschrift f{\"u}r Die Gesamte Experimentelle Medizin",

issn = "1591-8890",

publisher = "Springer-Verlag Italia",

}

TY - JOUR

T1 - T cells, mast cells and microvascular density in diffuse large B cell lymphoma

AU - Marinaccio, Christian

AU - Ingravallo, Giuseppe

AU - Gaudio, Francesco

AU - Perrone, Tommasina

AU - Ruggieri, Simona

AU - Opinto, Giuseppina

AU - Nico, Beatrice

AU - Maiorano, Eugenio

AU - Specchia, Giorgina

AU - Ribatti, Domenico

PY - 2015/5/10

Y1 - 2015/5/10

N2 - Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammatory infiltrate, T cells and mast cells have been demonstrated to be correlated with tumor angiogenesis. In this report, we have investigated CD3 and tryptase expression and their relationship with microvascular density (MVD) in DLBCL patients. Moreover, we determined the significance of CD3 expression in bulky and non-bulky disease. CD3 expression was significantly lower in bulky disease patients when compared to non-bulky ones. CD3 showed a positive correlation with tryptase and MVD, while multiple regression analysis efficaciously predicted MVD depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in DLBCL patients.

AB - Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammatory infiltrate, T cells and mast cells have been demonstrated to be correlated with tumor angiogenesis. In this report, we have investigated CD3 and tryptase expression and their relationship with microvascular density (MVD) in DLBCL patients. Moreover, we determined the significance of CD3 expression in bulky and non-bulky disease. CD3 expression was significantly lower in bulky disease patients when compared to non-bulky ones. CD3 showed a positive correlation with tryptase and MVD, while multiple regression analysis efficaciously predicted MVD depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in DLBCL patients.

KW - Angiogenesis

KW - Diffuse large B cell lymphoma

KW - Mast cells

KW - Microvascular density

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=84929094323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929094323&partnerID=8YFLogxK

U2 - 10.1007/s10238-015-0354-5

DO - 10.1007/s10238-015-0354-5

M3 - Article

AN - SCOPUS:84929094323

JO - Zeitschrift für Die Gesamte Experimentelle Medizin

JF - Zeitschrift für Die Gesamte Experimentelle Medizin

SN - 1591-8890

ER -