TY - JOUR
T1 - T cells, mast cells and microvascular density in diffuse large B cell lymphoma
AU - Marinaccio, Christian
AU - Ingravallo, Giuseppe
AU - Gaudio, Francesco
AU - Perrone, Tommasina
AU - Ruggieri, Simona
AU - Opinto, Giuseppina
AU - Nico, Beatrice
AU - Maiorano, Eugenio
AU - Specchia, Giorgina
AU - Ribatti, Domenico
PY - 2015/5/10
Y1 - 2015/5/10
N2 - Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammatory infiltrate, T cells and mast cells have been demonstrated to be correlated with tumor angiogenesis. In this report, we have investigated CD3 and tryptase expression and their relationship with microvascular density (MVD) in DLBCL patients. Moreover, we determined the significance of CD3 expression in bulky and non-bulky disease. CD3 expression was significantly lower in bulky disease patients when compared to non-bulky ones. CD3 showed a positive correlation with tryptase and MVD, while multiple regression analysis efficaciously predicted MVD depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in DLBCL patients.
AB - Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammatory infiltrate, T cells and mast cells have been demonstrated to be correlated with tumor angiogenesis. In this report, we have investigated CD3 and tryptase expression and their relationship with microvascular density (MVD) in DLBCL patients. Moreover, we determined the significance of CD3 expression in bulky and non-bulky disease. CD3 expression was significantly lower in bulky disease patients when compared to non-bulky ones. CD3 showed a positive correlation with tryptase and MVD, while multiple regression analysis efficaciously predicted MVD depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in DLBCL patients.
KW - Angiogenesis
KW - Diffuse large B cell lymphoma
KW - Mast cells
KW - Microvascular density
KW - T cells
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UR - http://www.scopus.com/inward/citedby.url?scp=84929094323&partnerID=8YFLogxK
U2 - 10.1007/s10238-015-0354-5
DO - 10.1007/s10238-015-0354-5
M3 - Article
AN - SCOPUS:84929094323
JO - Zeitschrift für Die Gesamte Experimentelle Medizin
JF - Zeitschrift für Die Gesamte Experimentelle Medizin
SN - 1591-8890
ER -