T-gamma lymphocytes in a case of congenital hypoplastic anemia (Diamond-Blackfan syndrome)

P. Cornaglia-Ferraris, R. Ghio, P. Mori, B. De Bernardi, M. Pasino, R. Sitia, L. Massimo

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed surface markers on lymphocytes from Bone Marrow (BM) and Peripheral Blood (PB) obtained from a patient with Diamond-Blackfan Syndrome (CHA). The percentage of T lymphocytes which carry the receptor for the Fc of IgG (T-gamma cells) was significantly increased in both PB and BM at onset of the disease. The serum of the patient fcontained a factor capable of drastically inhibition CFU-E and BFU-E, but not CFU-C ('blocking factor'). T-gamma cells returned to normal percentage after prednisone treatment. However, prednisone therapy did not alter the inhibitory activity of the serum 'blocking factor'. The possible roles of T-gamma cells and serum blocking factor in the pathogenesis of CHA are discussed. Our studies suggest an immunological mechanism in the disease process.

Original languageEnglish
Pages (from-to)269-278
Number of pages10
JournalHaematologica
Volume66
Issue number3
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Hematology

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