T-helper 2 involvement in the pathogenesis of bullous pemphigoid: Role of soluble CD30 (sCD30)

O. De Pitá, A. Frezzolini, G. Cianchini, M. Ruffelli, P. Teofoli, P. Puddu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Bullous pemphigoid (BP) is an autoimmune blistering skin disease in which autoantibodies are directed against hemidesmosomal proteins of basal keratinocytes. The presence of activated T helper cells in lesions and peripheral blood of BP patients, the eosinophilia, the high levels of serum IgE, eosinophil cationic protein and soluble immune products such as IL-2, sIL-2R, IL-5, soluble CD23 (sCD23) strongly suggest the involvement of a cell-mediated immune reaction in which Th2 lymphocytes could play a pivotal role. To seek evidence to support this hypothesis we evaluated serum levels of IL-4 and sCD30, a specific activation marker of cells able to produce Th2-like cytokines, in 25 patients affected with BP. Serum from both healthy donors and pemphigus vulgaris (PV) patients were used as controls. Our results demonstrated significantly higher levels of IL-4 and sCD30 in patients with BP in relation to both normal individuals (16.6 ± 7.9 vs 4.5 ± 2.2 pg/ml, P <0.0001; 30.3 ± 10 vs 10.5 ± 4 U/ml, P <0.0001) and PV patients (6.2 ± 4 pg/ml, P <0.0001; 16 ± 8.5 U/ml, P <0.0001). Furthermore, a positive correlation between IL-4 and sCD30 was found (R = 0.85, P <0.0001). In a subset of seven patients observed after systemic immunosuppressive therapy, we detected a significant reduction in sCD30 serum levels (36.9 ± 7.3 vs 16.3 ± 6.8 U/ml, P = 0.002), with a parallel improvement in their clinical condition. These results seem to be consistent with the systemic involvement of Th2 lymphocytes in the pathogenesis of BP and suggest a role for sCD30 as a serological marker of disease activity.

Original languageEnglish
Pages (from-to)667-670
Number of pages4
JournalArchives of Dermatological Research
Volume289
Issue number12
DOIs
Publication statusPublished - 1997

Fingerprint

Bullous Pemphigoid
Interleukin-4
Pemphigus
Serum
Lymphocytes
Eosinophil Cationic Protein
Interleukin-5
Eosinophilia
Immunosuppressive Agents
Helper-Inducer T-Lymphocytes
Keratinocytes
Skin Diseases
Autoantibodies
Immunoglobulin E
Interleukin-2
Tissue Donors
Cytokines
Proteins

Keywords

  • Bullous pemphigoid
  • Interleukin-4
  • sCD30
  • T-helper 2

ASJC Scopus subject areas

  • Dermatology

Cite this

De Pitá, O., Frezzolini, A., Cianchini, G., Ruffelli, M., Teofoli, P., & Puddu, P. (1997). T-helper 2 involvement in the pathogenesis of bullous pemphigoid: Role of soluble CD30 (sCD30). Archives of Dermatological Research, 289(12), 667-670. https://doi.org/10.1007/s004030050259

T-helper 2 involvement in the pathogenesis of bullous pemphigoid : Role of soluble CD30 (sCD30). / De Pitá, O.; Frezzolini, A.; Cianchini, G.; Ruffelli, M.; Teofoli, P.; Puddu, P.

In: Archives of Dermatological Research, Vol. 289, No. 12, 1997, p. 667-670.

Research output: Contribution to journalArticle

De Pitá, O, Frezzolini, A, Cianchini, G, Ruffelli, M, Teofoli, P & Puddu, P 1997, 'T-helper 2 involvement in the pathogenesis of bullous pemphigoid: Role of soluble CD30 (sCD30)', Archives of Dermatological Research, vol. 289, no. 12, pp. 667-670. https://doi.org/10.1007/s004030050259
De Pitá, O. ; Frezzolini, A. ; Cianchini, G. ; Ruffelli, M. ; Teofoli, P. ; Puddu, P. / T-helper 2 involvement in the pathogenesis of bullous pemphigoid : Role of soluble CD30 (sCD30). In: Archives of Dermatological Research. 1997 ; Vol. 289, No. 12. pp. 667-670.
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