T lymphocyte costimulation mediated by reorganization of membrane microdomains

Antonella Viola, Susanne Schroeder, Yoichi Sakakibara, Antonio Lanzavecchia

Research output: Contribution to journalArticlepeer-review

Abstract

Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down- regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.

Original languageEnglish
Pages (from-to)680-682
Number of pages3
JournalScience
Volume283
Issue number5402
DOIs
Publication statusPublished - Jan 29 1999

ASJC Scopus subject areas

  • General

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