T lymphocyte costimulation mediated by reorganization of membrane microdomains

Antonella Viola, Susanne Schroeder, Yoichi Sakakibara, Antonio Lanzavecchia

Research output: Contribution to journalArticle

Abstract

Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down- regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.

Original languageEnglish
Pages (from-to)680-682
Number of pages3
JournalScience
Volume283
Issue number5402
DOIs
Publication statusPublished - Jan 29 1999

Fingerprint

Membrane Microdomains
T-Cell Antigen Receptor
T-Lymphocytes
Intracellular Membranes
Cluster Analysis
Tyrosine
Phosphotransferases
Down-Regulation
Phosphorylation

ASJC Scopus subject areas

  • General

Cite this

Viola, A., Schroeder, S., Sakakibara, Y., & Lanzavecchia, A. (1999). T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science, 283(5402), 680-682. https://doi.org/10.1126/science.283.5402.680

T lymphocyte costimulation mediated by reorganization of membrane microdomains. / Viola, Antonella; Schroeder, Susanne; Sakakibara, Yoichi; Lanzavecchia, Antonio.

In: Science, Vol. 283, No. 5402, 29.01.1999, p. 680-682.

Research output: Contribution to journalArticle

Viola, A, Schroeder, S, Sakakibara, Y & Lanzavecchia, A 1999, 'T lymphocyte costimulation mediated by reorganization of membrane microdomains', Science, vol. 283, no. 5402, pp. 680-682. https://doi.org/10.1126/science.283.5402.680
Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science. 1999 Jan 29;283(5402):680-682. https://doi.org/10.1126/science.283.5402.680
Viola, Antonella ; Schroeder, Susanne ; Sakakibara, Yoichi ; Lanzavecchia, Antonio. / T lymphocyte costimulation mediated by reorganization of membrane microdomains. In: Science. 1999 ; Vol. 283, No. 5402. pp. 680-682.
@article{be63579458ea496195cd64d8e708c9ec,
title = "T lymphocyte costimulation mediated by reorganization of membrane microdomains",
abstract = "Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down- regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.",
author = "Antonella Viola and Susanne Schroeder and Yoichi Sakakibara and Antonio Lanzavecchia",
year = "1999",
month = "1",
day = "29",
doi = "10.1126/science.283.5402.680",
language = "English",
volume = "283",
pages = "680--682",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5402",

}

TY - JOUR

T1 - T lymphocyte costimulation mediated by reorganization of membrane microdomains

AU - Viola, Antonella

AU - Schroeder, Susanne

AU - Sakakibara, Yoichi

AU - Lanzavecchia, Antonio

PY - 1999/1/29

Y1 - 1999/1/29

N2 - Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down- regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.

AB - Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down- regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.

UR - http://www.scopus.com/inward/record.url?scp=0033613826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033613826&partnerID=8YFLogxK

U2 - 10.1126/science.283.5402.680

DO - 10.1126/science.283.5402.680

M3 - Article

C2 - 9924026

AN - SCOPUS:0033613826

VL - 283

SP - 680

EP - 682

JO - Science

JF - Science

SN - 0036-8075

IS - 5402

ER -