T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)

Laura Guazzarotti, Daria Trabattoni, Eleonora Castelletti, Benedetta Boldrighini, Luca Piacentini, Piergiorgio Duca, Silvia Beretta, Michela Pacei, Cristiana Caprio, Alessandra Viganò, Berardo Di Natale, Gian Vincenzo Zuccotti, Mario Clerici

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalAmerican Journal on Intellectual and Developmental Disabilities
Volume114
Issue number2
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Down Syndrome
Interleukin-7
Lymphocytes
T-Lymphocytes
Interleukins
Antigen-Antibody Complex
Serum
Interleukin-10
Interferon-gamma
Cytokines
Activation

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology
  • Medicine(all)

Cite this

T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome). / Guazzarotti, Laura; Trabattoni, Daria; Castelletti, Eleonora; Boldrighini, Benedetta; Piacentini, Luca; Duca, Piergiorgio; Beretta, Silvia; Pacei, Michela; Caprio, Cristiana; Viganò, Alessandra; Di Natale, Berardo; Zuccotti, Gian Vincenzo; Clerici, Mario.

In: American Journal on Intellectual and Developmental Disabilities, Vol. 114, No. 2, 03.2009, p. 100-109.

Research output: Contribution to journalArticle

Guazzarotti, L, Trabattoni, D, Castelletti, E, Boldrighini, B, Piacentini, L, Duca, P, Beretta, S, Pacei, M, Caprio, C, Viganò, A, Di Natale, B, Zuccotti, GV & Clerici, M 2009, 'T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)', American Journal on Intellectual and Developmental Disabilities, vol. 114, no. 2, pp. 100-109. https://doi.org/10.1352/2009.114:100-109
Guazzarotti, Laura ; Trabattoni, Daria ; Castelletti, Eleonora ; Boldrighini, Benedetta ; Piacentini, Luca ; Duca, Piergiorgio ; Beretta, Silvia ; Pacei, Michela ; Caprio, Cristiana ; Viganò, Alessandra ; Di Natale, Berardo ; Zuccotti, Gian Vincenzo ; Clerici, Mario. / T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome). In: American Journal on Intellectual and Developmental Disabilities. 2009 ; Vol. 114, No. 2. pp. 100-109.
@article{c5e1ff803d704a49bf51bd51d1a1a73a,
title = "T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)",
abstract = "Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.",
author = "Laura Guazzarotti and Daria Trabattoni and Eleonora Castelletti and Benedetta Boldrighini and Luca Piacentini and Piergiorgio Duca and Silvia Beretta and Michela Pacei and Cristiana Caprio and Alessandra Vigan{\`o} and {Di Natale}, Berardo and Zuccotti, {Gian Vincenzo} and Mario Clerici",
year = "2009",
month = "3",
doi = "10.1352/2009.114:100-109",
language = "English",
volume = "114",
pages = "100--109",
journal = "American Journal on Intellectual and Developmental Disabilities",
issn = "1944-7558",
publisher = "American Association on Intellectual and Developmental Disabilities",
number = "2",

}

TY - JOUR

T1 - T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)

AU - Guazzarotti, Laura

AU - Trabattoni, Daria

AU - Castelletti, Eleonora

AU - Boldrighini, Benedetta

AU - Piacentini, Luca

AU - Duca, Piergiorgio

AU - Beretta, Silvia

AU - Pacei, Michela

AU - Caprio, Cristiana

AU - Viganò, Alessandra

AU - Di Natale, Berardo

AU - Zuccotti, Gian Vincenzo

AU - Clerici, Mario

PY - 2009/3

Y1 - 2009/3

N2 - Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.

AB - Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.

UR - http://www.scopus.com/inward/record.url?scp=65549115151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549115151&partnerID=8YFLogxK

U2 - 10.1352/2009.114:100-109

DO - 10.1352/2009.114:100-109

M3 - Article

VL - 114

SP - 100

EP - 109

JO - American Journal on Intellectual and Developmental Disabilities

JF - American Journal on Intellectual and Developmental Disabilities

SN - 1944-7558

IS - 2

ER -