T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)

Laura Guazzarotti, Daria Trabattoni, Eleonora Castelletti, Benedetta Boldrighini, Luca Piacentini, Piergiorgio Duca, Silvia Beretta, Michela Pacei, Cristiana Caprio, Alessandra Viganò, Berardo Di Natale, Gian Vincenzo Zuccotti, Mario Clerici

Research output: Contribution to journalArticlepeer-review


Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalAmerican Journal on Intellectual and Developmental Disabilities
Issue number2
Publication statusPublished - Mar 2009

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology
  • Medicine(all)


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