TY - JOUR
T1 - T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians
AU - Sansoni, Paolo
AU - Fagnoni, Francesco
AU - Vescovini, Rosanna
AU - Mazzola, Marco
AU - Brianti, Vincenzo
AU - Bologna, Giovanni
AU - Nigro, Enrica
AU - Lavagetto, Giampaolo
AU - Cossarizza, Andrea
AU - Monti, Daniela
AU - Franceschi, Claudio
AU - Passeri, Mario
PY - 1997/6
Y1 - 1997/6
N2 - It is generally assumed that T cell proliferation is impaired in aged individuals. We report data on the proliferative capability of peripheral blood mononuclear cells (PBMC) and T lymphocytes from 40 healthy people of different ages, (19 - 107 years), including 14 centenarians, to defined mitogenic stimuli. We observed no age-related proliferative impairment both in PBMC and in purified T cells stimulated by anti-CD3 mAb or phorbol myristate acetate (PMA). Furthermore, T cells stimulated by anti-CD3 mAb or PMA and costimulated by CD28 mAb did not proliferate differently among young, middle aged subjects and centenarians. Thus, short term T cell proliferation is not affected even at extreme age when well defined stimuli are used on cells deriving from carefully selected healthy subjects.
AB - It is generally assumed that T cell proliferation is impaired in aged individuals. We report data on the proliferative capability of peripheral blood mononuclear cells (PBMC) and T lymphocytes from 40 healthy people of different ages, (19 - 107 years), including 14 centenarians, to defined mitogenic stimuli. We observed no age-related proliferative impairment both in PBMC and in purified T cells stimulated by anti-CD3 mAb or phorbol myristate acetate (PMA). Furthermore, T cells stimulated by anti-CD3 mAb or PMA and costimulated by CD28 mAb did not proliferate differently among young, middle aged subjects and centenarians. Thus, short term T cell proliferation is not affected even at extreme age when well defined stimuli are used on cells deriving from carefully selected healthy subjects.
KW - CD28
KW - Centenarians
KW - Proliferation
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=0030976833&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030976833&partnerID=8YFLogxK
U2 - 10.1016/S0047-6374(97)01887-3
DO - 10.1016/S0047-6374(97)01887-3
M3 - Article
C2 - 9223116
AN - SCOPUS:0030976833
VL - 96
SP - 127
EP - 136
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 1-3
ER -