T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians

Paolo Sansoni, Francesco Fagnoni, Rosanna Vescovini, Marco Mazzola, Vincenzo Brianti, Giovanni Bologna, Enrica Nigro, Giampaolo Lavagetto, Andrea Cossarizza, Daniela Monti, Claudio Franceschi, Mario Passeri

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Abstract

It is generally assumed that T cell proliferation is impaired in aged individuals. We report data on the proliferative capability of peripheral blood mononuclear cells (PBMC) and T lymphocytes from 40 healthy people of different ages, (19 - 107 years), including 14 centenarians, to defined mitogenic stimuli. We observed no age-related proliferative impairment both in PBMC and in purified T cells stimulated by anti-CD3 mAb or phorbol myristate acetate (PMA). Furthermore, T cells stimulated by anti-CD3 mAb or PMA and costimulated by CD28 mAb did not proliferate differently among young, middle aged subjects and centenarians. Thus, short term T cell proliferation is not affected even at extreme age when well defined stimuli are used on cells deriving from carefully selected healthy subjects.

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalMechanisms of Ageing and Development
Volume96
Issue number1-3
DOIs
Publication statusPublished - Jun 1997

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Keywords

  • CD28
  • Centenarians
  • Proliferation
  • T cells

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Sansoni, P., Fagnoni, F., Vescovini, R., Mazzola, M., Brianti, V., Bologna, G., Nigro, E., Lavagetto, G., Cossarizza, A., Monti, D., Franceschi, C., & Passeri, M. (1997). T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians. Mechanisms of Ageing and Development, 96(1-3), 127-136. https://doi.org/10.1016/S0047-6374(97)01887-3