We studied monoclonal antibody defined T-lymphocyte subsets from multiple sclerosis patients. A transverse study on 52 subjects confirmed that clinical relapses are related with a decrease of circulating T-suppressors. A sequential monthly analysis of T-cell subsets in 24 patients revealed that the subjects with clinical relapses showed fluctuations of T-suppressors of higher grade than clinically stable ones. The same subjects presented higher titres of anti-measles antibodies. Finally, a parallel study of blood and cerebrospinal fluid of 29 MS patients revealed that disease exacerbations are characterized by the same immunocyte abnormality in both the body fluids.
|Number of pages||10|
|Publication status||Published - 1985|
ASJC Scopus subject areas
- Clinical Neurology