Abstract
We studied monoclonal antibody defined T-lymphocyte subsets from multiple sclerosis patients. A transverse study on 52 subjects confirmed that clinical relapses are related with a decrease of circulating T-suppressors. A sequential monthly analysis of T-cell subsets in 24 patients revealed that the subjects with clinical relapses showed fluctuations of T-suppressors of higher grade than clinically stable ones. The same subjects presented higher titres of anti-measles antibodies. Finally, a parallel study of blood and cerebrospinal fluid of 29 MS patients revealed that disease exacerbations are characterized by the same immunocyte abnormality in both the body fluids.
Original language | English |
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Pages (from-to) | 328-337 |
Number of pages | 10 |
Journal | Acta Neurologica |
Volume | 40 |
Issue number | 3-4 |
Publication status | Published - 1985 |
ASJC Scopus subject areas
- Clinical Neurology