T-lymphocyte subpopulations in multiple sclerosis

M. Zaffaroni, D. Caputo, A. Ghezzi

Research output: Contribution to journalArticlepeer-review

Abstract

We studied monoclonal antibody defined T-lymphocyte subsets from multiple sclerosis patients. A transverse study on 52 subjects confirmed that clinical relapses are related with a decrease of circulating T-suppressors. A sequential monthly analysis of T-cell subsets in 24 patients revealed that the subjects with clinical relapses showed fluctuations of T-suppressors of higher grade than clinically stable ones. The same subjects presented higher titres of anti-measles antibodies. Finally, a parallel study of blood and cerebrospinal fluid of 29 MS patients revealed that disease exacerbations are characterized by the same immunocyte abnormality in both the body fluids.

Original languageEnglish
Pages (from-to)328-337
Number of pages10
JournalActa Neurologica
Volume40
Issue number3-4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Clinical Neurology

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