T lymphocyte subsets and colony growth in hairy-cell leukemia

Francesco Lauria, Robert Foà, Marco Gobbi, Estella Matutes, Wilma Mantovani, Enrico Incarbone, Sante Tura, Daniel Catovsky

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution of T cell subsets and the T colony-forming capacity were assessed in 22 patients with hairy-cell leukemia. An overall increase in the proportion of Tγ cells (31±15%) and a decrease in Tμ cells (38±11%) were observed if compared with normal controls (16±6% for Tγ and 51±13% for Tμ). In half of the patients, however, these values were normal. Tγ cells were highest in the splenectomized patients and in the 15 non-splenectomized patients Tγ cells were higher in those with active disease. Patients with stable disease or in remission had values close to normal. The T colony-forming capacity of unseparated and enriched T lymphocytes was normal regardless of the T cell subset distribution and clinical stage of the disease. These findings suggest that in HCL, unlike B cell chronic lymphocytic leukemia, the imbalance in Tμ/Tγ ratio does not result in an impairment of the in vitro T colony-forming capacity.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalLa Ricerca in Clinica e in Laboratorio
Volume12
Issue number4
DOIs
Publication statusPublished - Oct 1982

Keywords

  • Fc receptors for IgG
  • Fc receptors for IgM
  • Hairy-cell leukemia
  • T lymphocyte colonies

ASJC Scopus subject areas

  • Clinical Biochemistry

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