T lymphocyte subsets and colony growth in hairy-cell leukemia

Francesco Lauria, Robert Foà, Marco Gobbi, Estella Matutes, Wilma Mantovani, Enrico Incarbone, Sante Tura, Daniel Catovsky

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The distribution of T cell subsets and the T colony-forming capacity were assessed in 22 patients with hairy-cell leukemia. An overall increase in the proportion of Tγ cells (31±15%) and a decrease in Tμ cells (38±11%) were observed if compared with normal controls (16±6% for Tγ and 51±13% for Tμ). In half of the patients, however, these values were normal. Tγ cells were highest in the splenectomized patients and in the 15 non-splenectomized patients Tγ cells were higher in those with active disease. Patients with stable disease or in remission had values close to normal. The T colony-forming capacity of unseparated and enriched T lymphocytes was normal regardless of the T cell subset distribution and clinical stage of the disease. These findings suggest that in HCL, unlike B cell chronic lymphocytic leukemia, the imbalance in Tμ/Tγ ratio does not result in an impairment of the in vitro T colony-forming capacity.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalLa Ricerca in Clinica e in Laboratorio
Volume12
Issue number4
DOIs
Publication statusPublished - Oct 1982

Fingerprint

Hairy Cell Leukemia
T-cells
T-Lymphocyte Subsets
T-Lymphocytes
Growth
Hospital Distribution Systems
B-Cell Chronic Lymphocytic Leukemia
Reference Values
Cells

Keywords

  • Fc receptors for IgG
  • Fc receptors for IgM
  • Hairy-cell leukemia
  • T lymphocyte colonies

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Lauria, F., Foà, R., Gobbi, M., Matutes, E., Mantovani, W., Incarbone, E., ... Catovsky, D. (1982). T lymphocyte subsets and colony growth in hairy-cell leukemia. La Ricerca in Clinica e in Laboratorio, 12(4), 567-572. https://doi.org/10.1007/BF02909341

T lymphocyte subsets and colony growth in hairy-cell leukemia. / Lauria, Francesco; Foà, Robert; Gobbi, Marco; Matutes, Estella; Mantovani, Wilma; Incarbone, Enrico; Tura, Sante; Catovsky, Daniel.

In: La Ricerca in Clinica e in Laboratorio, Vol. 12, No. 4, 10.1982, p. 567-572.

Research output: Contribution to journalArticle

Lauria, F, Foà, R, Gobbi, M, Matutes, E, Mantovani, W, Incarbone, E, Tura, S & Catovsky, D 1982, 'T lymphocyte subsets and colony growth in hairy-cell leukemia', La Ricerca in Clinica e in Laboratorio, vol. 12, no. 4, pp. 567-572. https://doi.org/10.1007/BF02909341
Lauria, Francesco ; Foà, Robert ; Gobbi, Marco ; Matutes, Estella ; Mantovani, Wilma ; Incarbone, Enrico ; Tura, Sante ; Catovsky, Daniel. / T lymphocyte subsets and colony growth in hairy-cell leukemia. In: La Ricerca in Clinica e in Laboratorio. 1982 ; Vol. 12, No. 4. pp. 567-572.
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