T lymphocytes isolated from the peripheral blood of 20 aged humans were analyzed with regard to the phenotype and to the proliferation upon activation by lectin or alloantigens or autoantigens. The results show that the peripheral blood T lymphocytes or healthy aged donors are significantly different from those of young controls: (a) they contain lower percentages of OKT3+, OKT4+ and Fcμ+ cells and a higher percentage of OKT8+ lymphocytes. Moreover T lymphocytes from aged donors are poor responders upon activation in vitro by lectins, alloantigens and autoantigens and do not recognize the regulatory information of normal adherent suppressor cells. The relationships between these phenotypic and functional defects are discussed.
|Number of pages||2|
|Journal||IRCS Medical Science|
|Publication status||Published - 1983|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)