T lymphocyte subsets in aging humans: Phenotypic and functional analysis

D. Viglione, I. Pierri, S. Rogna

Research output: Contribution to journalArticlepeer-review


T lymphocytes isolated from the peripheral blood of 20 aged humans were analyzed with regard to the phenotype and to the proliferation upon activation by lectin or alloantigens or autoantigens. The results show that the peripheral blood T lymphocytes or healthy aged donors are significantly different from those of young controls: (a) they contain lower percentages of OKT3+, OKT4+ and Fcμ+ cells and a higher percentage of OKT8+ lymphocytes. Moreover T lymphocytes from aged donors are poor responders upon activation in vitro by lectins, alloantigens and autoantigens and do not recognize the regulatory information of normal adherent suppressor cells. The relationships between these phenotypic and functional defects are discussed.

Original languageEnglish
Pages (from-to)1070-1071
Number of pages2
JournalIRCS Medical Science
Issue number12
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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