Lymphocytes T dans la leucémie lymphatique chronique et variations de l'activité génétique

P. F. Conte; P. Masera; A. Pileri

Lymphocytes T dans la leucémie lymphatique chronique et variations de l'activité génétique

Translated title of the contribution: T-lymphocytes in chromic lymphatic leukemia and variations of genetic activity

P. F. Conte, P. Masera, A. Pileri

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.

Translated title of the contribution	T-lymphocytes in chromic lymphatic leukemia and variations of genetic activity
Original language	French
Pages (from-to)	1289-1292
Number of pages	4
Journal	Comptes rendus hebdomadaires des seances de l"Academie des sciences. Serie D: Sciences naturelles
Volume	281
Issue number	17
Publication status	Published - Oct 27 1975

ASJC Scopus subject areas

Medicine(all)

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title = "Lymphocytes T dans la leuc{\'e}mie lymphatique chronique et variations de l'activit{\'e} g{\'e}n{\'e}tique",

abstract = "By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.",

author = "Conte, {P. F.} and P. Masera and A. Pileri",

year = "1975",

month = oct,

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AU - Masera, P.

AU - Pileri, A.

PY - 1975/10/27

Y1 - 1975/10/27

N2 - By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.

AB - By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.

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AN - SCOPUS:0016863244

VL - 281

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JO - Comptes Rendus de l'Academie des Sciences, Paris, Serie D

JF - Comptes Rendus de l'Academie des Sciences, Paris, Serie D

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