Abstract
By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.
| Original language | French |
|---|---|
| Pages (from-to) | 1289-1292 |
| Number of pages | 4 |
| Journal | Comptes rendus hebdomadaires des seances de l"Academie des sciences. Serie D: Sciences naturelles |
| Volume | 281 |
| Issue number | 17 |
| Publication status | Published - Oct 27 1975 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Lymphocytes T dans la leucémie lymphatique chronique et variations de l'activité génétique. / Conte, P. F.; Masera, P.; Pileri, A.
In: Comptes rendus hebdomadaires des seances de l"Academie des sciences. Serie D: Sciences naturelles, Vol. 281, No. 17, 27.10.1975, p. 1289-1292.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Lymphocytes T dans la leucémie lymphatique chronique et variations de l'activité génétique
AU - Conte, P. F.
AU - Masera, P.
AU - Pileri, A.
PY - 1975/10/27
Y1 - 1975/10/27
N2 - By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.
AB - By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.
UR - http://www.scopus.com/inward/record.url?scp=0016863244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016863244&partnerID=8YFLogxK
M3 - Articolo
C2 - 819150
AN - SCOPUS:0016863244
VL - 281
SP - 1289
EP - 1292
JO - Comptes Rendus de l'Academie des Sciences, Paris, Serie D
JF - Comptes Rendus de l'Academie des Sciences, Paris, Serie D
SN - 0567-655X
IS - 17
ER -