By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.
|Translated title of the contribution||T-lymphocytes in chromic lymphatic leukemia and variations of genetic activity|
|Number of pages||4|
|Journal||Comptes rendus hebdomadaires des seances de l"Academie des sciences. Serie D: Sciences naturelles|
|Publication status||Published - Oct 27 1975|
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