Lymphocytes T dans la leucémie lymphatique chronique et variations de l'activité génétique

Translated title of the contribution: T-lymphocytes in chromic lymphatic leukemia and variations of genetic activity

P. F. Conte, P. Masera, A. Pileri

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.

Original languageFrench
Pages (from-to)1289-1292
Number of pages4
JournalComptes rendus hebdomadaires des seances de l"Academie des sciences. Serie D: Sciences naturelles
Volume281
Issue number17
Publication statusPublished - Oct 27 1975

Fingerprint

Leukemia
Lymphocytes
T-Lymphocytes
Dactinomycin
Chromatin
dilution
B-Lymphocytes
Population
leukaemia
method

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.",
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AU - Conte, P. F.

AU - Masera, P.

AU - Pileri, A.

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Y1 - 1975/10/27

N2 - By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.

AB - By using autoradiographic methods, we have studied the actinomycin-binding in nuclei of CLL's lymphocytes cultured, in presence of PHA, at varying cellular concentrations. Chromatin activation is earlier and greater in the most concentrated culture, which thus more closely resemble normal lymphocytes' cultures. This data supports the hypothesis that T cells in CLL have normal PHA-stimulability and that their apparently delayed response is due to dilution in a predominant B cell population.

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