T-lymphocytes phenotype and functions in patients with head and neck cancer

Ivana Pierri, Giovanni Cordone, Silvia Rogna, Cristina Piccardo, Andrea Barabino, Francesco Indiveri

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the phenotype of T-lymphocytes isolated from 18 patients with head and neck cancer, their capacity to express la antigens upon activation by lectins in vitro, their capacity to function either as responder or stimulator cells in autologous mixed lymphocyte reaction, and their capacity to cooperate with the normal adherent suppressor cells (NASC). The T-lymphocytes isolated from these patients have several functional defects including an impaired capacity to activate allogeneic lymphocytes in mixed lymphocyte reactions (MLRs), a lack of a proliferative capacity in autologous MLRs, an impaired sensitivity to inhibition by NASC, and an impaired capacity to express la antigens upon activation by mitogens in cilia. These data indicate that, in patients with head and neck cancer, immune function is characterized by a defect in T-lymphocytes functions which concerns the process of cell to cell cooperation.

Original languageEnglish
Pages (from-to)577-581
Number of pages5
JournalLaryngoscope
Volume95
Issue number5
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'T-lymphocytes phenotype and functions in patients with head and neck cancer'. Together they form a unique fingerprint.

Cite this