TY - JOUR
T1 - T reatment patterns with systemic antipsoriatic agents in childhood psoriasis
T2 - An Italian database analysis
AU - Di Lernia, Vito
AU - Neri, Iria
AU - Pintoton, Piergiacomo Calzavaraara
AU - Di Nuzzo, Sergio
AU - Stingeni, Luca
AU - Guarneri, Claudio
AU - Forti, Anna Belloni
AU - Bonamonte, Domenico
AU - Cambiaghi, Stefano
AU - Lasagni, Claudia
AU - Panzone, Michele
AU - Corazza, Monica
AU - Offidani, Annamaria
AU - Gisondi, Paolo
PY - 2017/8/1
Y1 - 2017/8/1
N2 - BACKGRO UND: The majority of available systemic therapies have never been systematically investigated in moderate to severe childhood plaque psoriasis. For this reason, treatment preferences for moderate to severe psoriasis in childhood are still unknown. The aim of this study was to investigate the systemic treatment patterns of moderate to severe psoriasis in children and adolescents aged 18 or older in Italy. Additional secondary outcomes were duration of treatment and reasons for discontinuation. METHODS: In order to define differences in treatment patterns, we performed a chart review of all consecutive patients treated with systemic drugs during an index period of 5 years. Consecutive sampling of all patients with psoriasis aged ?18 years, who had been treated with at least one systemic drug over a 5-year period, was made. RE SULTLTS: The records of 58 consecutive patients, 27 males, 31 females. with moderate to severe psoriasis treated with at least one systemic therapy were reviewed. The median age (standard deviation) at the start of the first systemic treatment was 11.7±3.7 years. The most preferred first-line systemic treatment was cyclosporine, which was administered as first systemic treatment in 53.4% of patients, followed by acitretin in 22.4% of patients, etanercept and PUVA respectively in 8.6%, methotrexate in 6.8%. 48.2% of patients received a second systemic treatment due to inefficacy or side effects of the first-line therapy during the index period. Because of the small sample, and voluntary contribution, selection bias may have occurred. CONCLUSIONS: A considerable variation in the management of the first-line systemic therapy in children with moderate to severe psoriasis was observed. Cyclosporine was most commonly preferred as a first-line treatment. The availability of new therapeutic agents could change the scenario of treatment patterns in childhood psoriasis.
AB - BACKGRO UND: The majority of available systemic therapies have never been systematically investigated in moderate to severe childhood plaque psoriasis. For this reason, treatment preferences for moderate to severe psoriasis in childhood are still unknown. The aim of this study was to investigate the systemic treatment patterns of moderate to severe psoriasis in children and adolescents aged 18 or older in Italy. Additional secondary outcomes were duration of treatment and reasons for discontinuation. METHODS: In order to define differences in treatment patterns, we performed a chart review of all consecutive patients treated with systemic drugs during an index period of 5 years. Consecutive sampling of all patients with psoriasis aged ?18 years, who had been treated with at least one systemic drug over a 5-year period, was made. RE SULTLTS: The records of 58 consecutive patients, 27 males, 31 females. with moderate to severe psoriasis treated with at least one systemic therapy were reviewed. The median age (standard deviation) at the start of the first systemic treatment was 11.7±3.7 years. The most preferred first-line systemic treatment was cyclosporine, which was administered as first systemic treatment in 53.4% of patients, followed by acitretin in 22.4% of patients, etanercept and PUVA respectively in 8.6%, methotrexate in 6.8%. 48.2% of patients received a second systemic treatment due to inefficacy or side effects of the first-line therapy during the index period. Because of the small sample, and voluntary contribution, selection bias may have occurred. CONCLUSIONS: A considerable variation in the management of the first-line systemic therapy in children with moderate to severe psoriasis was observed. Cyclosporine was most commonly preferred as a first-line treatment. The availability of new therapeutic agents could change the scenario of treatment patterns in childhood psoriasis.
KW - Acitretin
KW - Cyclosporine
KW - Methotrexate
KW - Pediatrics
KW - Psoriasis
KW - Therapeutics
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U2 - 10.23736/S0392-0488.16.05287-X
DO - 10.23736/S0392-0488.16.05287-X
M3 - Article
AN - SCOPUS:85020933789
VL - 152
SP - 327
EP - 332
JO - Minerva dermatologica
JF - Minerva dermatologica
SN - 0392-0488
IS - 4
ER -