T-regulatory 1 cells

A novel subset of CD4+T cells with immunoregulatory properties

Megan K. Levings, Maria Grazia Roncarolo

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Clonal deletion and clonal anergy are well established mechanisms of peripheral tolerance. A role has also been described for clonal suppression by regulatory cells in the induction of peripheral tolerance to a variety of antigens. However, it has been difficult to isolate regulatory cells and to define their mechanism of action. We have recently reported the in vitro generation and characterization of a novel subset of CD4+ T cells that have regulatory properties and are able to suppress antigen-specific immune responses in vitro and in vivo. These T-regulatory 1 (Tr1) cells are defined by their unique profile of cytokine production and make high levels of IL-10 and TGF-β, but no IL-4 or IL-2. The IL-10 and TGF-β produced by these cells mediate the inhibition of primary, naive T cells in vitro. There is also evidence that Tr1 cells exist in vivo, and we have documented the presence of high IL-10-producing CD4+ T cells in patients with severe combined immunodeficiency who have received allogeneic stem-cell transplants. These findings support the notion that Tr1 cells are involved in the regulation of peripheral tolerance and that they could potentially be used as a cellular therapy to modulate immune responses in vivo.

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
Volume106
Issue number1 II
Publication statusPublished - Jul 2000

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T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Peripheral Tolerance
Interleukin-10
Clonal Anergy
Clonal Deletion
T-Lymphocytes
Severe Combined Immunodeficiency
Histocompatibility Antigens Class II
Interleukin-4
Interleukin-2
Stem Cells
Cytokines
Transplants
Antigens
In Vitro Techniques
Therapeutics

Keywords

  • Anergy
  • Inflammatory bowel disease
  • Peripheral tolerance
  • Tr1 cells
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

T-regulatory 1 cells : A novel subset of CD4+T cells with immunoregulatory properties. / Levings, Megan K.; Roncarolo, Maria Grazia.

In: Journal of Allergy and Clinical Immunology, Vol. 106, No. 1 II, 07.2000.

Research output: Contribution to journalArticle

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