T-regulatory 1 cells: A novel subset of CD4+T cells with immunoregulatory properties

Megan K. Levings, Maria Grazia Roncarolo

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Clonal deletion and clonal anergy are well established mechanisms of peripheral tolerance. A role has also been described for clonal suppression by regulatory cells in the induction of peripheral tolerance to a variety of antigens. However, it has been difficult to isolate regulatory cells and to define their mechanism of action. We have recently reported the in vitro generation and characterization of a novel subset of CD4+ T cells that have regulatory properties and are able to suppress antigen-specific immune responses in vitro and in vivo. These T-regulatory 1 (Tr1) cells are defined by their unique profile of cytokine production and make high levels of IL-10 and TGF-β, but no IL-4 or IL-2. The IL-10 and TGF-β produced by these cells mediate the inhibition of primary, naive T cells in vitro. There is also evidence that Tr1 cells exist in vivo, and we have documented the presence of high IL-10-producing CD4+ T cells in patients with severe combined immunodeficiency who have received allogeneic stem-cell transplants. These findings support the notion that Tr1 cells are involved in the regulation of peripheral tolerance and that they could potentially be used as a cellular therapy to modulate immune responses in vivo.

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
Issue number1 II
Publication statusPublished - Jul 2000


  • Anergy
  • Inflammatory bowel disease
  • Peripheral tolerance
  • Tr1 cells
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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