T regulatory cells in contact hypersensitivity

Andrea Cavani

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE OF REVIEW: The review summarizes the recent investigations focused on T regulatory cells in hapten diseases. RECENT FINDINGS: Multiple mechanisms ensure tolerance to small chemicals penetrating the skin. Among these, specific T regulatory cells play a major role in controlling harmful immune responses to environmental antigens. Most of the T regulatory cells involved in this process belongs to the CD4 subset and suppress hapten-specific immune response through the release of IL-10 and through direct interaction with effector T cells, blocking their function. SUMMARY: Methods for in-vitro and in-vivo expansion of specific T regulatory cells may represent an innovative approach for the cure of contact hypersensitivity.

Original languageEnglish
Pages (from-to)294-298
Number of pages5
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume8
Issue number4
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Dendritic cells
  • Skin
  • T regulatory cells
  • Tolerance

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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