L'alternanza dell'onda T: Un nuovo metodo per individuare i pazienti a rischio di tachiaritmie ventricolari maligne

Translated title of the contribution: T wave alternans: A new tool for screening patients at high risk of malignant ventricular arrhythmias

Research output: Contribution to journalArticle


T wave alternans (TWA) is a change, in the microvolt range, of T wave amplitude on ABABAB se quence. TWA depends on heart rate, being optimally analyzed at a target frequency of 110 b/min. Initial studies used atrial pacing to reach the target frequency and reported a sensitivity and specificity of 89% for TWA in predicting tachyarrhythmic events. Subsequently, similar results were obtained using ergometric test to reach the target frequency, a less invasive and more "physiologic" approach to increase heart rate. This method became therefore the elective system to increase heart rate in order to evaluate the presence of TWA by means of spectral analysis. At present, various groups of high arrhythmic risk patients have been evaluated, including those with a recent myocardial infarction, congestive heart failure, implantable cardiac defibrillator and clinical indication to programmed ventricular stimulation. In all clinical conditions analyzed, TWA analysis demonstrated a good diagnostic accuracy, suggesting a possible clinical use of the test in these settings.

Original languageItalian
Pages (from-to)170-177
Number of pages8
JournalItalian Heart Journal Supplement
Issue number2
Publication statusPublished - 2002


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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