Abstract
Electrocardiographic signs of left ventricular hypertrophy (ECG-LVH) and T-wave axis (TA) deviation are independent predictors of fatal and non fatal events. We assessed the prevalence of ECG-LVH, TA abnormalities and their combination according to the presence or absence of diabetes and/or hypertension in a large sample of the adult general Italian population. Data from 10,184 women (54 ± 11 years) and 8775 men (54 ± 11 years) were analyzed from the Moli-sani cohort, a database of randomly recruited adults (age > 35) from the general population of Molise, a central region of Italy that includes collection of standard 12-lead resting ECG. Subjects with previous myocardial infarction, angina, cerebrovascular disease or left bundle brunch block or missing values for TA or ECG-LVH have been excluded. TA was measured from the standard 12-lead ECG and it was defined as the rotation of the T wave in the frontal plane as computed by a proprietary algorithm (CalECG/Bravo, AMPS-LLC, NY). ECG-LVH was defined as Sokolow Lyon voltage (SLv) > 35 mm or Cornell voltage duration Product (CP) > = 2440 mm*ms. Among subjects with ECG-LVH, prevalence of hypertension was 59.0% and 49.7%, respectively for men and women, whereas that of diabetes was 10.7% and 5.7%. In hypertensives, TA was normal in 72.3% of subjects, borderline in 24.8% and abnormal in 2.9%. In diabetics, TA was normal in 70.4% of subjects, borderline in 26.5% and abnormal in 3.1%. In both hypertensive and diabetic subjects, the prevalence of ECG-LVH, was significantly greater in subjects with borderline or abnormal TA. Hypertension was an independent predictor of abnormal TA (odd ratio: 1.38, P =.025). These results suggest that hypertension might play a relevant role in the pathogenesis of TA deviation.
| Original language | English |
|---|---|
| Pages (from-to) | 487-491 |
| Number of pages | 5 |
| Journal | Journal of Electrocardiology |
| Volume | 46 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 2013 |
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Keywords
- Coronary artery disease
- Diabetes
- Hypertension
- Left ventricular hypertrophy T-wave axes
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
T-wave axis deviation and left ventricular hypertrophy interaction in diabetes and hypertension. / Assanelli, Deodato; Di Castelnuovo, Augusto; Rago, Livia; Badilini, Fabio; Vinetti, Giovanni; Gianfagna, Francesco; Salvetti, Massimo; Zito, Francesco; Donati, Maria Benedetta; De Gaetano, Giovanni; Iacoviello, Licia.
In: Journal of Electrocardiology, Vol. 46, No. 6, 11.2013, p. 487-491.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T-wave axis deviation and left ventricular hypertrophy interaction in diabetes and hypertension
AU - Assanelli, Deodato
AU - Di Castelnuovo, Augusto
AU - Rago, Livia
AU - Badilini, Fabio
AU - Vinetti, Giovanni
AU - Gianfagna, Francesco
AU - Salvetti, Massimo
AU - Zito, Francesco
AU - Donati, Maria Benedetta
AU - De Gaetano, Giovanni
AU - Iacoviello, Licia
PY - 2013/11
Y1 - 2013/11
N2 - Electrocardiographic signs of left ventricular hypertrophy (ECG-LVH) and T-wave axis (TA) deviation are independent predictors of fatal and non fatal events. We assessed the prevalence of ECG-LVH, TA abnormalities and their combination according to the presence or absence of diabetes and/or hypertension in a large sample of the adult general Italian population. Data from 10,184 women (54 ± 11 years) and 8775 men (54 ± 11 years) were analyzed from the Moli-sani cohort, a database of randomly recruited adults (age > 35) from the general population of Molise, a central region of Italy that includes collection of standard 12-lead resting ECG. Subjects with previous myocardial infarction, angina, cerebrovascular disease or left bundle brunch block or missing values for TA or ECG-LVH have been excluded. TA was measured from the standard 12-lead ECG and it was defined as the rotation of the T wave in the frontal plane as computed by a proprietary algorithm (CalECG/Bravo, AMPS-LLC, NY). ECG-LVH was defined as Sokolow Lyon voltage (SLv) > 35 mm or Cornell voltage duration Product (CP) > = 2440 mm*ms. Among subjects with ECG-LVH, prevalence of hypertension was 59.0% and 49.7%, respectively for men and women, whereas that of diabetes was 10.7% and 5.7%. In hypertensives, TA was normal in 72.3% of subjects, borderline in 24.8% and abnormal in 2.9%. In diabetics, TA was normal in 70.4% of subjects, borderline in 26.5% and abnormal in 3.1%. In both hypertensive and diabetic subjects, the prevalence of ECG-LVH, was significantly greater in subjects with borderline or abnormal TA. Hypertension was an independent predictor of abnormal TA (odd ratio: 1.38, P =.025). These results suggest that hypertension might play a relevant role in the pathogenesis of TA deviation.
AB - Electrocardiographic signs of left ventricular hypertrophy (ECG-LVH) and T-wave axis (TA) deviation are independent predictors of fatal and non fatal events. We assessed the prevalence of ECG-LVH, TA abnormalities and their combination according to the presence or absence of diabetes and/or hypertension in a large sample of the adult general Italian population. Data from 10,184 women (54 ± 11 years) and 8775 men (54 ± 11 years) were analyzed from the Moli-sani cohort, a database of randomly recruited adults (age > 35) from the general population of Molise, a central region of Italy that includes collection of standard 12-lead resting ECG. Subjects with previous myocardial infarction, angina, cerebrovascular disease or left bundle brunch block or missing values for TA or ECG-LVH have been excluded. TA was measured from the standard 12-lead ECG and it was defined as the rotation of the T wave in the frontal plane as computed by a proprietary algorithm (CalECG/Bravo, AMPS-LLC, NY). ECG-LVH was defined as Sokolow Lyon voltage (SLv) > 35 mm or Cornell voltage duration Product (CP) > = 2440 mm*ms. Among subjects with ECG-LVH, prevalence of hypertension was 59.0% and 49.7%, respectively for men and women, whereas that of diabetes was 10.7% and 5.7%. In hypertensives, TA was normal in 72.3% of subjects, borderline in 24.8% and abnormal in 2.9%. In diabetics, TA was normal in 70.4% of subjects, borderline in 26.5% and abnormal in 3.1%. In both hypertensive and diabetic subjects, the prevalence of ECG-LVH, was significantly greater in subjects with borderline or abnormal TA. Hypertension was an independent predictor of abnormal TA (odd ratio: 1.38, P =.025). These results suggest that hypertension might play a relevant role in the pathogenesis of TA deviation.
KW - Coronary artery disease
KW - Diabetes
KW - Hypertension
KW - Left ventricular hypertrophy T-wave axes
UR - http://www.scopus.com/inward/record.url?scp=84886953070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886953070&partnerID=8YFLogxK
U2 - 10.1016/j.jelectrocard.2013.08.002
DO - 10.1016/j.jelectrocard.2013.08.002
M3 - Article
C2 - 24011993
AN - SCOPUS:84886953070
VL - 46
SP - 487
EP - 491
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
SN - 0022-0736
IS - 6
ER -