T-wave axis deviation, metabolic syndrome and cardiovascular risk: Results from the MOLI-SANI study

Deodato Assanelli, Livia Rago, Massimo Salvetti, Augusto Di Castelnuovo, Fabio Badilini, Martino Vaglio, Francesco Zito, Maria Benedetta Donati, Giovanni De Gaetano, Licia Iacoviello

Research output: Contribution to journalArticlepeer-review


Early recognition of patients at increased cardiovascular risk is a major challenge. The surface electrocardiogram provides a useful platform and it has been used to propose several indexes. T wave axis abnormality is associated with an increased risk of cardiovascular mortality, independently of other risk factors and can be associated with the presence of the metabolic syndrome (MetS). We assessed the prevalence of T axis abnormalities and its relationship with MetS and its components in a large population of Italian adults. Data concerning 11,143 women (54 ± 11 years) and 9742 men (55 ± 11 years) randomly recruited from a general population (Moli-sani cohort) were analyzed. After excluding subjects with incomplete data and with history of cardiac disease or left ventricular hypertrophy, T-wave axis was normal in 74.5% of men and 80.9% of women, borderline in 23.6% and 17.3% and abnormal in 1.9% and 1.8%. In subjects with MetS, the prevalence of borderline or abnormal T-wave axis deviation was higher than in subjects without MetS (in men: 26.6% vs. 22.1% and 2.5% vs. 1.7%; in women: 25% vs. 15% and 2.4% vs. 1.6%, respectively for borderline and abnormal levels, p <0.0001). Each component of MetS increased the odds of having borderline or abnormal T-wave axis deviation by 1.21 in men and 1.31 in women. T wave axis deviation is associated with MetS and its individual components. These findings confirm previous reported results, expanding them to a large and representative sample of European population of Caucasian ethnicity.

Original languageEnglish
Pages (from-to)546-550
Number of pages5
JournalJournal of Electrocardiology
Issue number6
Publication statusPublished - Nov 2012


  • Estimated cardiovascular risk
  • Metabolic syndrome
  • T-wave axes deviation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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