T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: Relation to iron content

Josef Vymazal, Andrea Righini, Rodney A. Brooks, Margherita Canesi, Claudio Mariani, Marco Leonardi, Gianni Pezzoli

Research output: Contribution to journalArticle

Abstract

PURPOSE: To investigate the potential of magnetic resonance imaging for identification and quantification of brain iron in healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy. MATERIALS AND METHODS: Forty-nine subjects were studied at 1.5 T. Regional T1 and T2 values were compared among groups and also with histopathologic estimates of iron concentration. RESULTS: In healthy subjects, interregional T1 and T2 differences in the cortex and basal ganglia showed a good correlation with reported values for iron concentration, and intraregional variations were generally consistent with reported variability of iron concentration. Patients with multiple system atrophy had T1 and T2 shortening in the globus pallidus consistent with reported increases in ferritin-iron and changes in the putamen consistent with accumulation of hemosiderin (posterior portion) and neuromelanin (remainder). Both groups of patients had changes in the cortex that are consistent with decreased ferritin concentration and T2 changes in white matter consistent with demyelination. Patients with Parkinson disease also had a (nonsignificant) T2 shortening in the substantia nigra that was suggestive of iron accumulation. CONCLUSION: Most of the T1 and T2 findings appear to be related to changes in iron content and form and may possibly be used as indicators of such changes.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalRadiology
Volume211
Issue number2
Publication statusPublished - May 1999

Fingerprint

Multiple System Atrophy
Parkinson Disease
Healthy Volunteers
Iron
Brain
Ferritins
Hemosiderin
Globus Pallidus
Putamen
Demyelinating Diseases
Substantia Nigra
Basal Ganglia
Magnetic Resonance Imaging

Keywords

  • Brain, iron
  • Brain, MR
  • Multiple system atrophy
  • Parkinson disease

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Vymazal, J., Righini, A., Brooks, R. A., Canesi, M., Mariani, C., Leonardi, M., & Pezzoli, G. (1999). T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: Relation to iron content. Radiology, 211(2), 489-495.

T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy : Relation to iron content. / Vymazal, Josef; Righini, Andrea; Brooks, Rodney A.; Canesi, Margherita; Mariani, Claudio; Leonardi, Marco; Pezzoli, Gianni.

In: Radiology, Vol. 211, No. 2, 05.1999, p. 489-495.

Research output: Contribution to journalArticle

Vymazal, J, Righini, A, Brooks, RA, Canesi, M, Mariani, C, Leonardi, M & Pezzoli, G 1999, 'T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: Relation to iron content', Radiology, vol. 211, no. 2, pp. 489-495.
Vymazal, Josef ; Righini, Andrea ; Brooks, Rodney A. ; Canesi, Margherita ; Mariani, Claudio ; Leonardi, Marco ; Pezzoli, Gianni. / T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy : Relation to iron content. In: Radiology. 1999 ; Vol. 211, No. 2. pp. 489-495.
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