T1 relaxation maps allow differentiation between pathologic tissue subsets in relapsing-remitting and secondary progressive multiple sclerosis

Alessandro Castriota-Scanderbeg, F. Fasano, M. Filippi, C. Caltagirone

Research output: Contribution to journalArticlepeer-review

Abstract

In an attempt to clarify whether T1 relaxation time mapping may assist in characterizing the pathological brain tissue substrate of multiple sclerosis (MS), we compared the T1 relaxation of lesions, areas of normal-appearing white matter (NAWM) located proximal to lesions, and areas of NAWM located distant from lesions in 12 patients with the relapsing-remitting and 12 with the secondary progressive (SP) subtype of disease. Nine healthy volunteers served as controls. Calculated mean T1 values were averaged across all patients within each clinical group, and comparisons were made by means of the Mann-Whitney U-test. Significant differences were found between all investigated brain regions within each clinical subgroup. Significant differences were also detected for each investigated brain region among clinical subgroups. While T1 values of NAWM were significantly higher in patients with SP disease than in normal white matter (NWM) of controls, no differences were detected when corresponding brain areas of patients with RR MS were compared with NWM of controls. T1 maps identify areas of the brain that are damaged to a different extent in patients with MS, and may be of help in monitoring disease progression.

Original languageEnglish
Pages (from-to)556-561
Number of pages6
JournalMultiple Sclerosis Journal
Volume10
Issue number5
DOIs
Publication statusPublished - Oct 2004

Keywords

  • Multiple sclerosis
  • Relapsing-remitting
  • Secondary psrogressive
  • T relaxation time

ASJC Scopus subject areas

  • Clinical Neurology

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