T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication

Hongxiang Liu, Hongtao Ye, Agnes RuskoneFourmestraux, Daphne De Jong, Stefano Pileri, Christian Thiede, Anne Lavergne, Henk Boot, Giancarlo Caletti, Thomas Wündisch, Thierry Molina, Babs G. Taal, Sabattini Elena, Togliani Thomas, Pier Luigi Zinzani, Andreas Neubauer, Manfred Stolte, Rifat A. Hamoudi, Ahmet Dogan, Peter G. IsaacsonMingQing Du

Research output: Contribution to journalArticle

Abstract

Background & Aims: Eradication of Helicobacter pylori leads to cure of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in 75% of localized cases. However, prolonged follow-up is necessary to determine whether a lymphoma responds to therapy. In a small series of cases, we showed that t(11;18)(q21;q21)-positive MALT lymphomas failed to respond to H. pylori eradication. The present study aimed to verify this finding in a large cohort and confirm whether the translocation predicts the response of stage IE tumors, for which clinical staging has little prognostic value. Methods: A total of 111 patients with H. pylori-positive gastric MALT lymphoma treated with antibiotics were studied. Clinical staging was undertaken before therapy. The response of lymphoma to H. pylori eradication was determined by histologic examination of gastric biopsy specimens. Diagnostic biopsy specimens were analyzed for t(11; 18)(q21;q21) by reverse-transcription polymerase chain reaction of the AP12-MALT1 transcript. Results: Forty-seven of the 48 patients who showed complete regression had lymphoma at stage IE, whereas 43 of the 63 nonresponsive cases were at stage IE and the remaining cases at stage IE, or above. t(11;18)(q21;q21) was detected in 2 of 48 complete-regression cases, and these positive cases showed relapse of lymphoma in the absence of H. pylori reinfection. In contrast, the translocation was present in 42 of the 63 nonresponsive cases, including 26 of 43 (60%) at stage IE. Conclusions: t(11; 18)(q21;q21)-positive gastric MALT lymphomas, including those at stage IE, do not respond to H. pylori eradication. Detection of the translocation should help the clinical management of patients with gastric MALT lymphoma.

Original languageEnglish
Pages (from-to)1286-1294
Number of pages9
JournalGastroenterology
Volume122
Issue number5
Publication statusPublished - 2002

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Marginal Zone B-Cell Lymphoma
Pylorus
Gastric Mucosa
Helicobacter pylori
Lymphoma
Biopsy
Reverse Transcription
Stomach
Anti-Bacterial Agents
Recurrence
Polymerase Chain Reaction
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology

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Liu, H., Ye, H., RuskoneFourmestraux, A., De Jong, D., Pileri, S., Thiede, C., ... Du, M. (2002). T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication. Gastroenterology, 122(5), 1286-1294.

T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication. / Liu, Hongxiang; Ye, Hongtao; RuskoneFourmestraux, Agnes; De Jong, Daphne; Pileri, Stefano; Thiede, Christian; Lavergne, Anne; Boot, Henk; Caletti, Giancarlo; Wündisch, Thomas; Molina, Thierry; Taal, Babs G.; Elena, Sabattini; Thomas, Togliani; Zinzani, Pier Luigi; Neubauer, Andreas; Stolte, Manfred; Hamoudi, Rifat A.; Dogan, Ahmet; Isaacson, Peter G.; Du, MingQing.

In: Gastroenterology, Vol. 122, No. 5, 2002, p. 1286-1294.

Research output: Contribution to journalArticle

Liu, H, Ye, H, RuskoneFourmestraux, A, De Jong, D, Pileri, S, Thiede, C, Lavergne, A, Boot, H, Caletti, G, Wündisch, T, Molina, T, Taal, BG, Elena, S, Thomas, T, Zinzani, PL, Neubauer, A, Stolte, M, Hamoudi, RA, Dogan, A, Isaacson, PG & Du, M 2002, 'T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication', Gastroenterology, vol. 122, no. 5, pp. 1286-1294.
Liu H, Ye H, RuskoneFourmestraux A, De Jong D, Pileri S, Thiede C et al. T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication. Gastroenterology. 2002;122(5):1286-1294.
Liu, Hongxiang ; Ye, Hongtao ; RuskoneFourmestraux, Agnes ; De Jong, Daphne ; Pileri, Stefano ; Thiede, Christian ; Lavergne, Anne ; Boot, Henk ; Caletti, Giancarlo ; Wündisch, Thomas ; Molina, Thierry ; Taal, Babs G. ; Elena, Sabattini ; Thomas, Togliani ; Zinzani, Pier Luigi ; Neubauer, Andreas ; Stolte, Manfred ; Hamoudi, Rifat A. ; Dogan, Ahmet ; Isaacson, Peter G. ; Du, MingQing. / T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication. In: Gastroenterology. 2002 ; Vol. 122, No. 5. pp. 1286-1294.
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abstract = "Background & Aims: Eradication of Helicobacter pylori leads to cure of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in 75{\%} of localized cases. However, prolonged follow-up is necessary to determine whether a lymphoma responds to therapy. In a small series of cases, we showed that t(11;18)(q21;q21)-positive MALT lymphomas failed to respond to H. pylori eradication. The present study aimed to verify this finding in a large cohort and confirm whether the translocation predicts the response of stage IE tumors, for which clinical staging has little prognostic value. Methods: A total of 111 patients with H. pylori-positive gastric MALT lymphoma treated with antibiotics were studied. Clinical staging was undertaken before therapy. The response of lymphoma to H. pylori eradication was determined by histologic examination of gastric biopsy specimens. Diagnostic biopsy specimens were analyzed for t(11; 18)(q21;q21) by reverse-transcription polymerase chain reaction of the AP12-MALT1 transcript. Results: Forty-seven of the 48 patients who showed complete regression had lymphoma at stage IE, whereas 43 of the 63 nonresponsive cases were at stage IE and the remaining cases at stage IE, or above. t(11;18)(q21;q21) was detected in 2 of 48 complete-regression cases, and these positive cases showed relapse of lymphoma in the absence of H. pylori reinfection. In contrast, the translocation was present in 42 of the 63 nonresponsive cases, including 26 of 43 (60{\%}) at stage IE. Conclusions: t(11; 18)(q21;q21)-positive gastric MALT lymphomas, including those at stage IE, do not respond to H. pylori eradication. Detection of the translocation should help the clinical management of patients with gastric MALT lymphoma.",
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T1 - T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication

AU - Liu, Hongxiang

AU - Ye, Hongtao

AU - RuskoneFourmestraux, Agnes

AU - De Jong, Daphne

AU - Pileri, Stefano

AU - Thiede, Christian

AU - Lavergne, Anne

AU - Boot, Henk

AU - Caletti, Giancarlo

AU - Wündisch, Thomas

AU - Molina, Thierry

AU - Taal, Babs G.

AU - Elena, Sabattini

AU - Thomas, Togliani

AU - Zinzani, Pier Luigi

AU - Neubauer, Andreas

AU - Stolte, Manfred

AU - Hamoudi, Rifat A.

AU - Dogan, Ahmet

AU - Isaacson, Peter G.

AU - Du, MingQing

PY - 2002

Y1 - 2002

N2 - Background & Aims: Eradication of Helicobacter pylori leads to cure of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in 75% of localized cases. However, prolonged follow-up is necessary to determine whether a lymphoma responds to therapy. In a small series of cases, we showed that t(11;18)(q21;q21)-positive MALT lymphomas failed to respond to H. pylori eradication. The present study aimed to verify this finding in a large cohort and confirm whether the translocation predicts the response of stage IE tumors, for which clinical staging has little prognostic value. Methods: A total of 111 patients with H. pylori-positive gastric MALT lymphoma treated with antibiotics were studied. Clinical staging was undertaken before therapy. The response of lymphoma to H. pylori eradication was determined by histologic examination of gastric biopsy specimens. Diagnostic biopsy specimens were analyzed for t(11; 18)(q21;q21) by reverse-transcription polymerase chain reaction of the AP12-MALT1 transcript. Results: Forty-seven of the 48 patients who showed complete regression had lymphoma at stage IE, whereas 43 of the 63 nonresponsive cases were at stage IE and the remaining cases at stage IE, or above. t(11;18)(q21;q21) was detected in 2 of 48 complete-regression cases, and these positive cases showed relapse of lymphoma in the absence of H. pylori reinfection. In contrast, the translocation was present in 42 of the 63 nonresponsive cases, including 26 of 43 (60%) at stage IE. Conclusions: t(11; 18)(q21;q21)-positive gastric MALT lymphomas, including those at stage IE, do not respond to H. pylori eradication. Detection of the translocation should help the clinical management of patients with gastric MALT lymphoma.

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