t(1;7) in acute myeloblastic leukemia following myelodysplastic syndrome (RAEB-T)

R. Defferrari, M. Sessarego, G. Santini, F. Ajmar

Research output: Contribution to journalArticle

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Abstract

A case is described of myelodysplastic syndrome (MDS) refractory anemia type with an excess of blasts in transformation with early leukemic evolution (AML-M1). All bone marrow cells examined showed an unbalanced translocation t(1;7). The karyotype was 45, xy, -21, -7, + der dic t(1;7)(q12;q21). There are reports in the literature of the translocation t(1;7)(p11;p11), which leads to trisomy of the long arms of chromosome number 1 and monosomy of the long arms of chromosome number 7. In the case here described the breakpoints of the chromosomes involved in the translocation differ from the classic ones: in this case there is trisomy of the region 1q12→1qter and monosomy of the region 7q21→7qter. Some clinical and cytogenetic considerations are suggested.

Original languageEnglish
Pages (from-to)555-558
Number of pages4
JournalTumori
Volume74
Issue number5
Publication statusPublished - 1988

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Refractory Anemia with Excess of Blasts
Monosomy
Myelodysplastic Syndromes
Trisomy
Acute Myeloid Leukemia
Chromosome Breakpoints
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 1
Lymphocyte Activation
Karyotype
Cytogenetics
Bone Marrow Cells

ASJC Scopus subject areas

  • Cancer Research

Cite this

Defferrari, R., Sessarego, M., Santini, G., & Ajmar, F. (1988). t(1;7) in acute myeloblastic leukemia following myelodysplastic syndrome (RAEB-T). Tumori, 74(5), 555-558.

t(1;7) in acute myeloblastic leukemia following myelodysplastic syndrome (RAEB-T). / Defferrari, R.; Sessarego, M.; Santini, G.; Ajmar, F.

In: Tumori, Vol. 74, No. 5, 1988, p. 555-558.

Research output: Contribution to journalArticle

Defferrari, R, Sessarego, M, Santini, G & Ajmar, F 1988, 't(1;7) in acute myeloblastic leukemia following myelodysplastic syndrome (RAEB-T)', Tumori, vol. 74, no. 5, pp. 555-558.
Defferrari R, Sessarego M, Santini G, Ajmar F. t(1;7) in acute myeloblastic leukemia following myelodysplastic syndrome (RAEB-T). Tumori. 1988;74(5):555-558.
Defferrari, R. ; Sessarego, M. ; Santini, G. ; Ajmar, F. / t(1;7) in acute myeloblastic leukemia following myelodysplastic syndrome (RAEB-T). In: Tumori. 1988 ; Vol. 74, No. 5. pp. 555-558.
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