t(1;7) in acute myeloblastic leukemia following myelodysplastic syndrome (RAEB-T)

R. Defferrari, M. Sessarego, G. Santini, F. Ajmar

Research output: Contribution to journalArticle

Abstract

A case is described of myelodysplastic syndrome (MDS) refractory anemia type with an excess of blasts in transformation with early leukemic evolution (AML-M1). All bone marrow cells examined showed an unbalanced translocation t(1;7). The karyotype was 45, xy, -21, -7, + der dic t(1;7)(q12;q21). There are reports in the literature of the translocation t(1;7)(p11;p11), which leads to trisomy of the long arms of chromosome number 1 and monosomy of the long arms of chromosome number 7. In the case here described the breakpoints of the chromosomes involved in the translocation differ from the classic ones: in this case there is trisomy of the region 1q12→1qter and monosomy of the region 7q21→7qter. Some clinical and cytogenetic considerations are suggested.

Original languageEnglish
Pages (from-to)555-558
Number of pages4
JournalTumori
Volume74
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cancer Research

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  • Cite this

    Defferrari, R., Sessarego, M., Santini, G., & Ajmar, F. (1988). t(1;7) in acute myeloblastic leukemia following myelodysplastic syndrome (RAEB-T). Tumori, 74(5), 555-558.