T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients

Speranza Rubattu; Marco de Giusti; Alessio Farcomeni; Sofia Abbolito; Filomena Comito; Sara Cangianiello; Ettore S. Greco; Eleonora Dito; Beniamino Pagliaro; Maria Cotugno; Rosita Stanzione; Simona Marchitti; Franca Bianchi; Sara Di Castro; Allegra Battistoni; Simone Burocchi; Massimo Caprinozzi; Giorgia Pierelli; Sebastiano Sciarretta; Massimo Volpe

doi:10.2459/JCM.0000000000000195

T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients

Speranza Rubattu, Marco de Giusti, Alessio Farcomeni, Sofia Abbolito, Filomena Comito, Sara Cangianiello, Ettore S. Greco, Eleonora Dito, Beniamino Pagliaro, Maria Cotugno, Rosita Stanzione, Simona Marchitti, Franca Bianchi, Sara Di Castro, Allegra Battistoni, Simone Burocchi, Massimo Caprinozzi, Giorgia Pierelli, Sebastiano Sciarretta, Massimo Volpe

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Abstract

BACKGROUND: The role of C2238/atrial natriuretic peptide (ANP) minor allele, at the T2238C ANP gene variant, as a predisposing risk factor for acute cardiovascular events, has been previously reported. We aimed at evaluating, by a retrospective approach, the long-term impact of C2238/ANP-minor allele carrier status toward the risk of recurrent acute coronary syndromes (re-ACS) in an Italian cohort of ischemic heart disease patients.

METHODS: A total of 379 patients (males?=?80.5%; mean age?=?62.5?±?9.2 years) presenting with ACS were retrospectively analyzed. Mean follow-up was 5.1?±?3.5 years (range 1–26 years). Occurrence of new episodes of unstable angina, non-ST-segment elevation myocardial infarction and STE myocardial infarction over the years was recorded and compared between subjects not carrying and carrying C2238/ANP-minor allele.

RESULTS: At univariate analysis, C2238/ANP-minor allele carrier status and treatment with beta-blocker, aspirin and statin were associated with risk of re-ACS. Multivariate analysis confirmed that hypercholesterolemia (P?

CONCLUSIONS: The present results demonstrate that C2238/ANP-minor allele carrier status is an independent risk factor for ACS recurrence in an Italian cohort of ischemic heart disease patients over the long term, and they support the role of C2238/ANP-minor allele as a negative prognostic factor in coronary artery disease patients.

Original language	English
Journal	Journal of Cardiovascular Medicine
DOIs	https://doi.org/10.2459/JCM.0000000000000195
Publication status	Accepted/In press - Sep 23 2014

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Rubattu, S., de Giusti, M., Farcomeni, A., Abbolito, S., Comito, F., Cangianiello, S., Greco, E. S., Dito, E., Pagliaro, B., Cotugno, M., Stanzione, R., Marchitti, S., Bianchi, F., Di Castro, S., Battistoni, A., Burocchi, S., Caprinozzi, M., Pierelli, G., Sciarretta, S., & Volpe, M. (Accepted/In press). T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients. Journal of Cardiovascular Medicine. https://doi.org/10.2459/JCM.0000000000000195

T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients. / Rubattu, Speranza; de Giusti, Marco; Farcomeni, Alessio; Abbolito, Sofia; Comito, Filomena; Cangianiello, Sara; Greco, Ettore S.; Dito, Eleonora; Pagliaro, Beniamino; Cotugno, Maria ; Stanzione, Rosita ; Marchitti, Simona ; Bianchi, Franca; Di Castro, Sara; Battistoni, Allegra; Burocchi, Simone; Caprinozzi, Massimo; Pierelli, Giorgia; Sciarretta, Sebastiano; Volpe, Massimo.

In: Journal of Cardiovascular Medicine, 23.09.2014.

Research output: Contribution to journal › Article › peer-review

Rubattu, S, de Giusti, M, Farcomeni, A, Abbolito, S, Comito, F, Cangianiello, S, Greco, ES, Dito, E, Pagliaro, B, Cotugno, M , Stanzione, R , Marchitti, S , Bianchi, F, Di Castro, S, Battistoni, A, Burocchi, S, Caprinozzi, M, Pierelli, G, Sciarretta, S & Volpe, M 2014, 'T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients', Journal of Cardiovascular Medicine. https://doi.org/10.2459/JCM.0000000000000195

Rubattu, Speranza ; de Giusti, Marco ; Farcomeni, Alessio ; Abbolito, Sofia ; Comito, Filomena ; Cangianiello, Sara ; Greco, Ettore S. ; Dito, Eleonora ; Pagliaro, Beniamino ; Cotugno, Maria ; Stanzione, Rosita ; Marchitti, Simona ; Bianchi, Franca ; Di Castro, Sara ; Battistoni, Allegra ; Burocchi, Simone ; Caprinozzi, Massimo ; Pierelli, Giorgia ; Sciarretta, Sebastiano ; Volpe, Massimo. / T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients. In: Journal of Cardiovascular Medicine. 2014.

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title = "T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients",

abstract = "BACKGROUND: The role of C2238/atrial natriuretic peptide (ANP) minor allele, at the T2238C ANP gene variant, as a predisposing risk factor for acute cardiovascular events, has been previously reported. We aimed at evaluating, by a retrospective approach, the long-term impact of C2238/ANP-minor allele carrier status toward the risk of recurrent acute coronary syndromes (re-ACS) in an Italian cohort of ischemic heart disease patients.METHODS: A total of 379 patients (males?=?80.5%; mean age?=?62.5?±?9.2 years) presenting with ACS were retrospectively analyzed. Mean follow-up was 5.1?±?3.5 years (range 1–26 years). Occurrence of new episodes of unstable angina, non-ST-segment elevation myocardial infarction and STE myocardial infarction over the years was recorded and compared between subjects not carrying and carrying C2238/ANP-minor allele.RESULTS: At univariate analysis, C2238/ANP-minor allele carrier status and treatment with beta-blocker, aspirin and statin were associated with risk of re-ACS. Multivariate analysis confirmed that hypercholesterolemia (P?CONCLUSIONS: The present results demonstrate that C2238/ANP-minor allele carrier status is an independent risk factor for ACS recurrence in an Italian cohort of ischemic heart disease patients over the long term, and they support the role of C2238/ANP-minor allele as a negative prognostic factor in coronary artery disease patients.",

author = "Speranza Rubattu and {de Giusti}, Marco and Alessio Farcomeni and Sofia Abbolito and Filomena Comito and Sara Cangianiello and Greco, {Ettore S.} and Eleonora Dito and Beniamino Pagliaro and Maria Cotugno and Rosita Stanzione and Simona Marchitti and Franca Bianchi and {Di Castro}, Sara and Allegra Battistoni and Simone Burocchi and Massimo Caprinozzi and Giorgia Pierelli and Sebastiano Sciarretta and Massimo Volpe",

year = "2014",

month = sep,

day = "23",

doi = "10.2459/JCM.0000000000000195",

language = "English",

journal = "Journal of Cardiovascular Medicine",

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TY - JOUR

T1 - T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients

AU - Rubattu, Speranza

AU - de Giusti, Marco

AU - Farcomeni, Alessio

AU - Abbolito, Sofia

AU - Comito, Filomena

AU - Cangianiello, Sara

AU - Greco, Ettore S.

AU - Dito, Eleonora

AU - Pagliaro, Beniamino

AU - Cotugno, Maria

AU - Stanzione, Rosita

AU - Marchitti, Simona

AU - Bianchi, Franca

AU - Di Castro, Sara

AU - Battistoni, Allegra

AU - Burocchi, Simone

AU - Caprinozzi, Massimo

AU - Pierelli, Giorgia

AU - Sciarretta, Sebastiano

AU - Volpe, Massimo

PY - 2014/9/23

Y1 - 2014/9/23

N2 - BACKGROUND: The role of C2238/atrial natriuretic peptide (ANP) minor allele, at the T2238C ANP gene variant, as a predisposing risk factor for acute cardiovascular events, has been previously reported. We aimed at evaluating, by a retrospective approach, the long-term impact of C2238/ANP-minor allele carrier status toward the risk of recurrent acute coronary syndromes (re-ACS) in an Italian cohort of ischemic heart disease patients.METHODS: A total of 379 patients (males?=?80.5%; mean age?=?62.5?±?9.2 years) presenting with ACS were retrospectively analyzed. Mean follow-up was 5.1?±?3.5 years (range 1–26 years). Occurrence of new episodes of unstable angina, non-ST-segment elevation myocardial infarction and STE myocardial infarction over the years was recorded and compared between subjects not carrying and carrying C2238/ANP-minor allele.RESULTS: At univariate analysis, C2238/ANP-minor allele carrier status and treatment with beta-blocker, aspirin and statin were associated with risk of re-ACS. Multivariate analysis confirmed that hypercholesterolemia (P?CONCLUSIONS: The present results demonstrate that C2238/ANP-minor allele carrier status is an independent risk factor for ACS recurrence in an Italian cohort of ischemic heart disease patients over the long term, and they support the role of C2238/ANP-minor allele as a negative prognostic factor in coronary artery disease patients.

AB - BACKGROUND: The role of C2238/atrial natriuretic peptide (ANP) minor allele, at the T2238C ANP gene variant, as a predisposing risk factor for acute cardiovascular events, has been previously reported. We aimed at evaluating, by a retrospective approach, the long-term impact of C2238/ANP-minor allele carrier status toward the risk of recurrent acute coronary syndromes (re-ACS) in an Italian cohort of ischemic heart disease patients.METHODS: A total of 379 patients (males?=?80.5%; mean age?=?62.5?±?9.2 years) presenting with ACS were retrospectively analyzed. Mean follow-up was 5.1?±?3.5 years (range 1–26 years). Occurrence of new episodes of unstable angina, non-ST-segment elevation myocardial infarction and STE myocardial infarction over the years was recorded and compared between subjects not carrying and carrying C2238/ANP-minor allele.RESULTS: At univariate analysis, C2238/ANP-minor allele carrier status and treatment with beta-blocker, aspirin and statin were associated with risk of re-ACS. Multivariate analysis confirmed that hypercholesterolemia (P?CONCLUSIONS: The present results demonstrate that C2238/ANP-minor allele carrier status is an independent risk factor for ACS recurrence in an Italian cohort of ischemic heart disease patients over the long term, and they support the role of C2238/ANP-minor allele as a negative prognostic factor in coronary artery disease patients.

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DO - 10.2459/JCM.0000000000000195

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JO - Journal of Cardiovascular Medicine

JF - Journal of Cardiovascular Medicine

SN - 1558-2027

ER -

T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients

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