T2238C atrial natriuretic peptide gene variant and cardiovascular events in patients with atrial fibrillation: A substudy from the ATHERO-AF cohort

Daniele Pastori, Roberto Carnevale, Rosita Stanzione, Cristina Nocella, Maria Cotugno, Simona Marchitti, Franca Bianchi, Maurizio Forte, Valentina Valenti, Giuseppe Biondi-Zoccai, Sonia Schiavon, Daniele Vecchio, Francesco Versaci, Giacomo Frati, Francesco Violi, Massimo Volpe, Pasquale Pignatelli, Speranza Rubattu, Sebastiano Sciarretta

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: The T2238C variant of the atrial natriuretic peptide (ANP) gene has emerged as a novel risk factor for the incidence of cardiovascular events. However, the impact of this variant on cardiovascular outcome in patients with atrial fibrillation (AF) is unknown.

METHODS: We included 557 anticoagulated patients with non-valvular AF randomly selected from the prospective ATHERO-AF cohort. Patients underwent genetic analysis for the T2238C/ANP variant and were grouped as wild type or heterozygous or homozygous for C2238 variant allele. Primary endpoint was a composite of cardiovascular events (CVEs) including cardiovascular death, fatal/non-fatal ischemic stroke and myocardial infarction. Overall, 429 patients carried the TT wild type genotype, 110 patients (19.7%) were heterozygous (T/C) and 18 patients (3.2%) were homozygous (CC).

RESULTS: Incidence of CVEs was higher in homozygous patients for C2238 allele at unadjusted analysis (log-rank test, p = 0.042 for additive model, p = 0.043 for recessive model). The multivariable Cox proportional hazards regression analysis confirmed that C2238 ANP allele was associated with CVEs in the additive (p = 0.008) and recessive models (p = 0.005).

CONCLUSIONS: Carrier status for the C2238/ANP variant allele is associated with an increased risk of CVEs in anticoagulated AF patients.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalInternational Journal of Cardiology
Volume322
DOIs
Publication statusPublished - Jan 1 2021

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