T4+ cell depletion as a major risk factor for AIDS-related complex and AIDS. Longitudinal study of 253 HIV-antibody positive heroin addicts from northern Italy

D. Conte, C. Mandelli, B. M. Cesana, R. Barbera, G. P. Aimo, W. Piubello, P. A. Bianchi

Research output: Contribution to journalArticle

Abstract

We enrolled 253 HIV-antibody positive heroin addicts without HIV-related disease (n = 81) or with persistent generalized lymphadenopathy (n = 172) in a prospective study to evaluate clinical progression to AIDS related complex (ARC) or AIDS and to identify factors of possible prognostic relevance. Follow-up lasted between 6 and 40 months (median 12 months). According to the non-parametric Cox's model the only significant (P <0.001) prognostic variable was T4+ cell count considered in three classes: > 800/μl (no depletion), 400-800/μl (moderate depletion) and 800/μl or between 400 and 800/μl respectively. The estimated probability of progression to ARC or AIDS was 0.029, 0.056 and 0.172 at one year in subjects with T4+ cell count of >800/μl, 400-800/μl and

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalInternational Journal of STD and AIDS
Volume2
Issue number1
Publication statusPublished - 1991

Keywords

  • AIDS
  • AIDS-related complex
  • Heroin addicts
  • HIV

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Microbiology (medical)
  • Public Health, Environmental and Occupational Health

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