t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia

Cristina Morerio, Maura Acquila, Cristina Rosanda, Annamaria Rapella, Elisa Tassano, Concetta Micalizzi, Claudio Panarello

Research output: Contribution to journalArticlepeer-review

Abstract

The rare t(9;11)(p22;p15) translocation is associated with adult acute myeloid leukemia (AML) with immature forms. We report a novel fusion of the NUP98 and LEDGF genes in a pediatric AML with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes exhibiting the same chromosomal rearrangement. Fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR) studies identified the chimeric transcript product of in-frame fusion of NUP98 exon 8 to LEDGF exon 4.

Original languageEnglish
Pages (from-to)467-470
Number of pages4
JournalLeukemia Research
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 2005

Keywords

  • NUP98-LEDGF fusion gene
  • t(9 ;11)(p22 ;p15)
  • Transitional M2-M3 acute myeloid leukemia

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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