TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: An open label study

Chi Un Pae, Antonio Drago, Jung Jin Kim, Ashwin A. Patkar, Tae Youn Jun, Chul Lee, Laura Mandelli, Diana De Ronchi, In Ho Paik, Alessandro Serretti

Research output: Contribution to journalArticle

Abstract

We recently reported an association between TAAR6 (trace amine associated receptor 6 gene) variations and schizophrenia (SZ). We now report an association of a set of TAAR6 variations and clinical presentation and outcome in a sample of 240 SZ Korean patients. Patients were selected by a Structured Clinical Interview, DSM-IV Axis I disorders - Clinical Version (SCID-CV). Other psychiatric or neurologic disorders, as well as medical diseases, were exclusion criteria. To assess symptom severity, patients were administered the CGI scale and the PANSS at baseline and at the moment of discharge, 1 month later on average. TAAR6 variations rs6903874, rs7452939, rs8192625 and rs4305745 were investigated; rs6903874, rs7452939 and rs8192625 entered the statistical investigation after LD analysis. Rs8192625 G/G homozygosis was found to be significantly associated both with a worse clinical presentation at PANSS total and positive scores and with a shorter period of illness before hospitalization. No haplotype significant findings were found. The present study stands for a role of the TAAR6 in the clinical presentation of SZ. Moreover, our results show that this genetic effect may be counteracted by a correct treatment. Haplotype analysis was not informative in our sample, probably also because of the incomplete SNPs' coverage of the gene we performed. Further studies in this direction are warranted.

Original languageEnglish
Pages (from-to)390-395
Number of pages6
JournalEuropean Psychiatry
Volume23
Issue number6
DOIs
Publication statusPublished - Sep 2008

Keywords

  • Association
  • Gene
  • Schizophrenia
  • Trace amine associated receptor 6

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: An open label study'. Together they form a unique fingerprint.

  • Cite this

    Pae, C. U., Drago, A., Kim, J. J., Patkar, A. A., Jun, T. Y., Lee, C., Mandelli, L., De Ronchi, D., Paik, I. H., & Serretti, A. (2008). TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: An open label study. European Psychiatry, 23(6), 390-395. https://doi.org/10.1016/j.eurpsy.2008.04.004