Tachykinins and excitotoxicity in cerebellar granule cells

Cinzia Severini, Cristina Zona

Research output: Contribution to journalArticle

Abstract

The tachykinins represent an important group of neuropeptides that are widely distributed both in the central and peripheral nervous system where they perform several functions connected with neuronal modulation, often in synergy with glutamate excitatory transmission. While a great deal of data is available on their distribution and many studies have been performed by molecular, biochemical, and immunohistochemical techniques, much less is known about their physiological role, in particular in the cerebellum. This review is an attempt to summarize the diverse evidence suggesting a role for tachykinins in cerebellar granule neurons.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalCerebellum
Volume5
Issue number3
DOIs
Publication statusPublished - Sep 1 2006

Keywords

  • Excitotoxicity
  • Glutamate receptors
  • NKA
  • NKB
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

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