Tactile and proprioceptive temporal discrimination are impaired in functional tremor

Michele Tinazzi, Alfonso Fasano, Alessia Peretti, Francesco Bove, Antonella Conte, Carlo Dall'Occhio, Carla Arbasino, Giovanni Defazio, Mirta Fiorio, Alfredo Berardelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Methods: In order to obtain further information on the pathophysiology of functional tremor, we assessed tactile discrimination threshold and proprioceptive temporal discrimination motor threshold values in 11 patients with functional tremor, 11 age- and sex-matched patients with essential tremor and 13 healthy controls. Results: Tactile discrimination threshold in both the right and left side was significantly higher in patients with functional tremor than in the other groups. Proprioceptive temporal discrimination threshold for both right and left side was significantly higher in patients with functional and essential tremor than in healthy controls. No significant correlation between discrimination thresholds and duration or severity of tremor was found. Conclusions: Temporal processing of tactile and proprioceptive stimuli is impaired in patients with functional tremor. The mechanisms underlying this impaired somatosensory processing and possible ways to apply these findings clinically merit further research.

Original languageEnglish
Article numbere102328
JournalPLoS One
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 22 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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