Tactile stimulation evokes long-term synaptic plasticity in the granular layer of cerebellum

Leda Roggeri, Bruno Rivieccio, Paola Rossi, Egidio D'Angelo

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Several forms of long-term synaptic plasticity [long-term potentiation (LTP) and long-term depression (LTD)] have been reported in the cerebellar circuit in vitro, but their determination in vivo was still lacking in most cases. Here we show that, in the urethane-anesthetized rat, appropriate patterns of facial tactile stimulation as well as intracerebellar electrical stimulation can induce LTP and LTD in local field potentials recorded from the granular layer of Crus-IIa. LTD prevailed in control conditions, whereas LTP prevailed during local application of gabazine. No relevant plasticity was observed when gabazine and APV were coapplied. The pharmacological and kinetic properties of LTP and LTD in vivo were compatible with those reported in the granule cell layer in vitro (Mapelli and D'Angelo, 2007), suggesting that NMDA receptor-dependent plasticity was generated at the mossy fiber-granule cell synapse under the inhibitory control of the Golgi cell circuit. Interestingly, LTP and LTD were able to regulate the response latency to tactile stimulation, as expected from computational modeling of the expression mechanisms (Nieus et al., 2006). This result suggests that LTP and LTD could regulate the spatiotemporal pattern of granular layer responses to mossy fiber inputs.

Original languageEnglish
Pages (from-to)6354-6359
Number of pages6
JournalJournal of Neuroscience
Volume28
Issue number25
DOIs
Publication statusPublished - Jun 18 2008

Fingerprint

Neuronal Plasticity
Long-Term Potentiation
Touch
Cerebellum
Depression
Urethane
N-Methyl-D-Aspartate Receptors
Synapses
Electric Stimulation
Reaction Time
Pharmacology

Keywords

  • Cerebellum
  • Granular layer
  • In vivo
  • LTD
  • LTP
  • Tactile stimulation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Tactile stimulation evokes long-term synaptic plasticity in the granular layer of cerebellum. / Roggeri, Leda; Rivieccio, Bruno; Rossi, Paola; D'Angelo, Egidio.

In: Journal of Neuroscience, Vol. 28, No. 25, 18.06.2008, p. 6354-6359.

Research output: Contribution to journalArticle

Roggeri, Leda ; Rivieccio, Bruno ; Rossi, Paola ; D'Angelo, Egidio. / Tactile stimulation evokes long-term synaptic plasticity in the granular layer of cerebellum. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 25. pp. 6354-6359.
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