Abstract
Clinical data of 92 patients with primary breast carcinomas previously analysed for the pattern of immunohistochemical expression of three distinct carbohydrate epitopes of the TAG-72 molecule were reviewed. The clinical outcome of the patients after a median follow-up of 66 months was determined in 84 out of 92 patients. Clinicopathological characteristics of the tumours and clinical outcome of the patients were correlated with the TAG-72 epitope expression. TAG-72 was expressed more frequently in patients aged more than 50 years and in tumours of larger size, with lymph nodes metastasis, with low differentiation and with high proliferative activity. A statistical correlation was found with more advanced stages of the disease (35.7% vs 60% in stage I and in stage II-III, respectively, p=0.03). Disease-free survival and overall survival were estimated by the Kaplan-Meier method. The survival of the patients with tumours expressing TAG-72 was not statistically different from that of patients with tumours without TAG-72 expression. These data suggest that TAG-72 expression is associated with clinicopathological parameters of aggressiveness in primary breast cancer, but it does not appear to affect the clinical outcome of the patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1399-1403 |
| Number of pages | 5 |
| Journal | Oncology Reports |
| Volume | 6 |
| Issue number | 6 |
| Publication status | Published - Nov 1999 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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TAG-72 expression and clinical outcome in primary breast cancer. / Pizzi, C.; Sgambato, A.; De Laurentiis, M.; Limite, G.; Panico, L.; Pettinato, G.; Muraro, R.; Tauchmanova, L.; Galietta, A.; Bianco, A. R.; Mariani-Costantini, R.; Contegiacomo, A.
In: Oncology Reports, Vol. 6, No. 6, 11.1999, p. 1399-1403.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - TAG-72 expression and clinical outcome in primary breast cancer.
AU - Pizzi, C.
AU - Sgambato, A.
AU - De Laurentiis, M.
AU - Limite, G.
AU - Panico, L.
AU - Pettinato, G.
AU - Muraro, R.
AU - Tauchmanova, L.
AU - Galietta, A.
AU - Bianco, A. R.
AU - Mariani-Costantini, R.
AU - Contegiacomo, A.
PY - 1999/11
Y1 - 1999/11
N2 - Clinical data of 92 patients with primary breast carcinomas previously analysed for the pattern of immunohistochemical expression of three distinct carbohydrate epitopes of the TAG-72 molecule were reviewed. The clinical outcome of the patients after a median follow-up of 66 months was determined in 84 out of 92 patients. Clinicopathological characteristics of the tumours and clinical outcome of the patients were correlated with the TAG-72 epitope expression. TAG-72 was expressed more frequently in patients aged more than 50 years and in tumours of larger size, with lymph nodes metastasis, with low differentiation and with high proliferative activity. A statistical correlation was found with more advanced stages of the disease (35.7% vs 60% in stage I and in stage II-III, respectively, p=0.03). Disease-free survival and overall survival were estimated by the Kaplan-Meier method. The survival of the patients with tumours expressing TAG-72 was not statistically different from that of patients with tumours without TAG-72 expression. These data suggest that TAG-72 expression is associated with clinicopathological parameters of aggressiveness in primary breast cancer, but it does not appear to affect the clinical outcome of the patients.
AB - Clinical data of 92 patients with primary breast carcinomas previously analysed for the pattern of immunohistochemical expression of three distinct carbohydrate epitopes of the TAG-72 molecule were reviewed. The clinical outcome of the patients after a median follow-up of 66 months was determined in 84 out of 92 patients. Clinicopathological characteristics of the tumours and clinical outcome of the patients were correlated with the TAG-72 epitope expression. TAG-72 was expressed more frequently in patients aged more than 50 years and in tumours of larger size, with lymph nodes metastasis, with low differentiation and with high proliferative activity. A statistical correlation was found with more advanced stages of the disease (35.7% vs 60% in stage I and in stage II-III, respectively, p=0.03). Disease-free survival and overall survival were estimated by the Kaplan-Meier method. The survival of the patients with tumours expressing TAG-72 was not statistically different from that of patients with tumours without TAG-72 expression. These data suggest that TAG-72 expression is associated with clinicopathological parameters of aggressiveness in primary breast cancer, but it does not appear to affect the clinical outcome of the patients.
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M3 - Article
VL - 6
SP - 1399
EP - 1403
JO - Oncology Reports
JF - Oncology Reports
SN - 1021-335X
IS - 6
ER -