Tailored breast cancer screening program with microdose mammography, us, and mr imaging: Short-term results of a pilot study in 40-49-year-old wome

Elena Venturini, Claudio Losio, Pietro Panizza, Maria Grazia Rodighiero, Isabella Fedele, Simona Tacchini, Elena Schiani, Silvia Ravelli, Giulia Cristel, Marta Maria Panzeri, FRAsco De Cobelli, Alessandro Del Maschio

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate the feasibility, performance, and cost of a breast cancer screening program aimed at 40-49-year-old women and tailored to their risk profile with supplemental ultrasonography (US) and magnetic resonance (MR) imaging. Materials and Methods: The institutional review board approved this study, and informed written consent was obtained. A total of 3017 40-49-year-old women were invited to participate. The screening program was tailored to lifetime risk (Gail test) and mammographic density (according to Breast Imaging Reporting and Data Systems [BI-RADS] criteria) with supplemental US or MR imaging and bilateral two-view microdose mammography. The indicators suggested by European guidelines, US incremental cancer detection rate (CDR), and estimated costs were evaluated. Results: A total of 1666 women (67.5% participation rate) were recruited. The average lifetime risk of breast cancer was 11.6%, and nine women had a high risk of breast cancer; 917 women (55.0%) had a high density score (BI-RADS density category 3 or 4). The average glandular dose for screening examinations was 1.49 mGy. Screening US was performed in 835 study participants (50.1%), mostly due to high breast density (800 of 1666 women [48.0%]). Screening MR imaging was performed in nine women (0.5%) at high risk for breast cancer. Breast cancer was diagnosed in 14 women (8.4 cases per 1000 women). Twelve diagnoses were made with microdose mammography, and two were made with supplemental US in dense breasts (2.4 cases per 1000 women). All patients were submitted for surgery, and 10 underwent breast-conserving surgery. The sentinel lymph node was evaluated in 11 patients, resulting in negative findings in six. Pathologic analysis resulted in the diagnosis of four ductal carcinomas in situ and 10 invasive carcinomas (five at stage I). Conclusion: A tailored breast cancer screening program in 40-49-yearold women yielded a greater-than-expected number of cancers, most of which were low-stage disease.

Original languageEnglish
Pages (from-to)347-355
Number of pages9
Issue number2
Publication statusPublished - Aug 2013

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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