Tailoring the hybrid palliation for hypoplastic left heart syndrome: A simulation study using a lumped parameter model

A. Di Molfetta, M. Pilati, M. G. Gagliardi, L. Fresiello, A. Amodeo, A. Cristofaletti, G. Pongiglione, G. Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

The results of Hybrid procedure (HP) for the hypoplastic left heart syndrome (HLHS) depend on several variables: pulmonary artery banding tightness (PAB), atrial septal defect size (ASD) and patent ductus arteriosus stent size (PDA). A HP complication could be the aortic coarctaction (CoAo). The reverse Blalock-Taussig shunt (RevBT) placement was proposed to avoid CoAo effects. This work aims at developing a lumped parameter model (LPM) to investigate the effects of the different variables on HP haemodynamics. A preliminary verification was performed collecting measurements on a newborn HLHS patient to calculate LPM input parameters to reproduce patient's baseline. Results suggest that haemodynamics is affected by ASD (ASD: 0.15-0.55 cm, pulmonary to systemic flow ratio Q p/Q s: 0.73-1, cardiac output (CO): 1-1.5 l/min and ventricular stroke work SW: 336-577 ml mmHg) and by the PAB diameter (PAB: 0.07-0.2 cm, Q p/Q s: 0.46-2.1, CO: 1.3-1.6 l/min and SW: 591-535 ml mmHg). Haemodynamics was neither affected by RevBT diameter nor by PDA diameter higher than 0.2 cm. RevBT implantation does not change the HP haemodynamics, but it can make the CoAo effect negligible. LPM could be useful to support clinical decision in complex physiopathology and to calibrate and personalise the parameters that play a role on flow distribution.

Original languageEnglish
Pages (from-to)898-904
Number of pages7
JournalMedical Engineering and Physics
Volume37
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Congenital heart defects
  • Hypoplastic left heart syndrome
  • Lumped parameter models

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

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