Tailoring treatment for ductal intraepithelial neoplasia of the breast according to Ki-67 and molecular phenotype

M. Lazzeroni, A. Guerrieri-Gonzaga, E. Botteri, M. C. Leonardi, N. Rotmensz, D. Serrano, C. Varricchio, D. Disalvatore, A. Del Castillo, F. Bassi, G. Pagani, A. Decensi, G. Viale, B. Bonanni, G. Pruneri

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The post-surgical management of ductal intraepithelial neoplasia (DIN) of the breast is still a dilemma. Ki-67 labelling index (LI) has been proposed as an independent predictive and prognostic factor in early breast cancer.Methods:The prognostic and predictive roles of Ki-67 LI were evaluated with a multivariable Cox regression model in a cohort of 1171 consecutive patients operated for DIN in a single institution from 1997 to 2007.Results:Radiotherapy (RT) was protective in subjects with DIN with Ki-67 LI ≥14%, whereas no evidence of benefit was seen for Ki-67 LI

Original languageEnglish
Pages (from-to)1593-1601
Number of pages9
JournalBritish Journal of Cancer
Volume108
Issue number8
DOIs
Publication statusPublished - Apr 30 2013

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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