Abstract
Takotsubo cardiomyopathy is a syndrome characterized by acute regional systolic dysfunction of the left ventricle, frequently related to psycho-physical acute stress, and usually reversible. This rare syndrome involves more often the female sex with the highest frequency of occurrence between the seventh and eighth decade of life. Etiology has not been clarified yet and several hypotheses have been postulated: multiple epicardial coronary artery damage, abnormal coronary microcirculation, catecholamine-mediated cardiac toxicity, and neurogenic stunning. Clinical presentation is not easy to distinguish from an acute coronary syndrome: chest pain at rest or dyspnea, new-onset electrocardiographic changes, characterized by ST-segment elevation or T-wave inversion. Coronary angiography, which should be performed within 48 h of symptom onset in order to be diagnostic, excludes the presence of significant atherosclerotic stenosis or plaque rupture. Ventricular angiography shows the typical regional wall motion abnormalities (apical akinesia and hyperkinesia of the mid-basal segments) that give to the syndrome its name (takotsubo is a traditional Japanese octopus trap or pot). Echocardiography performed in the acute phase also evidences wall motion abnormalities that characteristically regress in the following days. There is no specific treatment for this syndrome, but supportive and symptomatic therapy is usually administered.
| Original language | Italian |
|---|---|
| Pages (from-to) | 785-797 |
| Number of pages | 13 |
| Journal | Giornale Italiano di Cardiologia |
| Volume | 9 |
| Issue number | 11 |
| Publication status | Published - Nov 2008 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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La cardiomiopatia takotsubo : Documento di consenso. / Novo, Salvatore; Akashi, Yoshihiro; Arbustini, Eloisa; Assennato, Pasquale; Azzarelli, Salvatore; Barbaro, Giuseppe; Fazio, Giovanni; Fedele, Francesco; Giordan, Massimo; Mazzarotto, Pietro; Modena, Maria Grazia; Novo, Giuseppina; Parodi, Guido; Previtali, Mario; Rapezzi, Claudio; Sconci, Francesca; Sganzerla, Paolo; Tona, Francesco; Salerno-Uriarte, Jorge A.
In: Giornale Italiano di Cardiologia, Vol. 9, No. 11, 11.2008, p. 785-797.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - La cardiomiopatia takotsubo
T2 - Documento di consenso
AU - Novo, Salvatore
AU - Akashi, Yoshihiro
AU - Arbustini, Eloisa
AU - Assennato, Pasquale
AU - Azzarelli, Salvatore
AU - Barbaro, Giuseppe
AU - Fazio, Giovanni
AU - Fedele, Francesco
AU - Giordan, Massimo
AU - Mazzarotto, Pietro
AU - Modena, Maria Grazia
AU - Novo, Giuseppina
AU - Parodi, Guido
AU - Previtali, Mario
AU - Rapezzi, Claudio
AU - Sconci, Francesca
AU - Sganzerla, Paolo
AU - Tona, Francesco
AU - Salerno-Uriarte, Jorge A.
PY - 2008/11
Y1 - 2008/11
N2 - Takotsubo cardiomyopathy is a syndrome characterized by acute regional systolic dysfunction of the left ventricle, frequently related to psycho-physical acute stress, and usually reversible. This rare syndrome involves more often the female sex with the highest frequency of occurrence between the seventh and eighth decade of life. Etiology has not been clarified yet and several hypotheses have been postulated: multiple epicardial coronary artery damage, abnormal coronary microcirculation, catecholamine-mediated cardiac toxicity, and neurogenic stunning. Clinical presentation is not easy to distinguish from an acute coronary syndrome: chest pain at rest or dyspnea, new-onset electrocardiographic changes, characterized by ST-segment elevation or T-wave inversion. Coronary angiography, which should be performed within 48 h of symptom onset in order to be diagnostic, excludes the presence of significant atherosclerotic stenosis or plaque rupture. Ventricular angiography shows the typical regional wall motion abnormalities (apical akinesia and hyperkinesia of the mid-basal segments) that give to the syndrome its name (takotsubo is a traditional Japanese octopus trap or pot). Echocardiography performed in the acute phase also evidences wall motion abnormalities that characteristically regress in the following days. There is no specific treatment for this syndrome, but supportive and symptomatic therapy is usually administered.
AB - Takotsubo cardiomyopathy is a syndrome characterized by acute regional systolic dysfunction of the left ventricle, frequently related to psycho-physical acute stress, and usually reversible. This rare syndrome involves more often the female sex with the highest frequency of occurrence between the seventh and eighth decade of life. Etiology has not been clarified yet and several hypotheses have been postulated: multiple epicardial coronary artery damage, abnormal coronary microcirculation, catecholamine-mediated cardiac toxicity, and neurogenic stunning. Clinical presentation is not easy to distinguish from an acute coronary syndrome: chest pain at rest or dyspnea, new-onset electrocardiographic changes, characterized by ST-segment elevation or T-wave inversion. Coronary angiography, which should be performed within 48 h of symptom onset in order to be diagnostic, excludes the presence of significant atherosclerotic stenosis or plaque rupture. Ventricular angiography shows the typical regional wall motion abnormalities (apical akinesia and hyperkinesia of the mid-basal segments) that give to the syndrome its name (takotsubo is a traditional Japanese octopus trap or pot). Echocardiography performed in the acute phase also evidences wall motion abnormalities that characteristically regress in the following days. There is no specific treatment for this syndrome, but supportive and symptomatic therapy is usually administered.
KW - Diagnosis
KW - Takotsubo cardiomyopathy
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=57149105602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57149105602&partnerID=8YFLogxK
M3 - Articolo
C2 - 19058673
AN - SCOPUS:57149105602
VL - 9
SP - 785
EP - 797
JO - Giornale Italiano di Cardiologia
JF - Giornale Italiano di Cardiologia
SN - 1827-6806
IS - 11
ER -