The effect of 17β-Estradiol (E2) and antiestrogen Tamoxifen (TAM) on cell proliferation, estrogen receptor (ER) and progesterone receptor (PR) content was investigated in a human malignant melanoma cell line (SK Mel 28). TAM induced a slight decrease in cell growth at 10-6 M, while provoked a cytotoxic effect at 10-5 M. In contrast, E2 was ineffective on cell proliferation at all concentrations tested. ER and PR were determined by both biochemical and immunocytochemical assay. Preliminary results indicate that ER are scarcely represented, while PR are almost absent.
|Number of pages||10|
|Journal||Acta Medica Romana|
|Publication status||Published - 1994|
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