Tamoxifen, but not estradiol, modulates the growth of a human melanoma cell line

G. Lama, G. Sica, N. Bruzzese, S. L. Nori, S. D'Atri, M. Turriziani, E. Bonmassar

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of 17β-Estradiol (E2) and antiestrogen Tamoxifen (TAM) on cell proliferation, estrogen receptor (ER) and progesterone receptor (PR) content was investigated in a human malignant melanoma cell line (SK Mel 28). TAM induced a slight decrease in cell growth at 10-6 M, while provoked a cytotoxic effect at 10-5 M. In contrast, E2 was ineffective on cell proliferation at all concentrations tested. ER and PR were determined by both biochemical and immunocytochemical assay. Preliminary results indicate that ER are scarcely represented, while PR are almost absent.

Original languageEnglish
Pages (from-to)521-530
Number of pages10
JournalActa Medica Romana
Volume32
Issue number4
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Tamoxifen, but not estradiol, modulates the growth of a human melanoma cell line'. Together they form a unique fingerprint.

Cite this