Tamoxifen chemoprevention of a hormone-independent tumor in the proto- neu transgenic mice model

Sylvie Ménard, Piera Aiello, Elda Tagliabue, Cristiano Rumio, Pier Luigi Lollini, Maria I. Colnaghi, Andrea Balsari

Research output: Contribution to journalArticle

Abstract

We evaluated the effect of tamoxifen (TAM) on tumor development in proto-neu transgenic mice that spontaneously develop mammary carcinomas overexpressing the neu protein. These mammary carcinomas are hormone independent because superimposable growth of transplants was observed in females and males. Virgin transgenic mice treated with TAM from 24 weeks of age, i.e., when subclinical mammary tumors are already present, showed a slightly accelerated tumor development. In contrast, transgenic mice treated with TAM starting at 12 weeks of age, when subclinical tumors are not yet present, showed a 50% reduction of tumor incidence. Light microscopy analysis of the mammary gland of these mice revealed an apparently normal ductal branching but a complete regression of the acini. In conclusion, TAM can prevent the occurrence of hormone-independent breast carcinoma if given early enough to inhibit normal cells.

Original languageEnglish
Pages (from-to)273-275
Number of pages3
JournalCancer Research
Volume60
Issue number2
Publication statusPublished - Jan 15 2000

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Ménard, S., Aiello, P., Tagliabue, E., Rumio, C., Lollini, P. L., Colnaghi, M. I., & Balsari, A. (2000). Tamoxifen chemoprevention of a hormone-independent tumor in the proto- neu transgenic mice model. Cancer Research, 60(2), 273-275.