Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association

Diego Segala, Stefano Gobbo, Anna Pesci, Guido Martignoni, Angela Santoro, Giuseppe Angelico, Damiano Arciuolo, Saveria Spadola, Michele Valente, Giovanni Scambia, Gian Franco Zannoni

Research output: Contribution to journalReview article

Abstract

It is well known that a large number of patients treated with Tamoxifen develops endometrial pathologies ranging from benign endometrial polyps and hyperplasia to adenocarcinomas, carcinosarcomas and adenosarcomas. UTROSCT (Uterine Tumor Resembling Ovarian Sex Cord Tumor) is defined as a mesenchymal tumors of the uterine corpus that morphologically resembles ovarian sex cord tumors, without recognizable endometrial stroma. To date only 4 cases have been reported in patients treated with tamoxifen. In this article, we describe an additional case occurring in a 62-years-old patient undergoing 3 years of Tamoxifen therapy for bilateral breast carcinoma. The present work represents a further evidence of the possible association between Tamoxifen therapy and UTROSCT. A comprehensive literature review on this topic is also provided.

Original languageEnglish
Pages (from-to)1089-1092
Number of pages4
JournalPathology Research and Practice
Volume215
Issue number5
DOIs
Publication statusPublished - May 2019

Keywords

  • Breast Neoplasms/drug therapy
  • Carcinoma, Ductal, Breast/drug therapy
  • Comorbidity
  • Female
  • Humans
  • Leiomyoma/epidemiology
  • Middle Aged
  • Selective Estrogen Receptor Modulators/adverse effects
  • Sex Cord-Gonadal Stromal Tumors/chemically induced
  • Tamoxifen/adverse effects
  • Uterine Neoplasms/chemically induced

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