Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart

P. Abete, G. Testa, G. Galizia, F. Mazzella, D. Della Morte, D. De Santis, C. Calabrese, F. Cacciatore, G. Gargiulo, N. Ferrara, G. Rengo, V. Sica, C. Napoli, F. Rengo

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Ischemic preconditioning (IP) has been proposed as an endogenous form of protection against ischemia reperfusion injury. IP, however, does not prevent post-ischemic dysfunction in the aging heart but may be partially corrected by exercise training and food restriction. We investigated the role of exercise training combined with food restriction on restoring IP in the aging heart. Effects of IP against ischemia-reperfusion injury in isolated hearts from adult (A, 6 months old), sedentary 'ad libitum' fed (SL), trained ad libitum fed (TL), sedentary food-restricted (SR), trained- and food-restricted senescent rats (TR) (24 months old) were investigated. Norepinephrine release in coronary effluent was determined by high performance liquid cromatography. IP significantly improved final recovery of percent developed pressure in hearts from A (p

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalExperimental Gerontology
Volume40
Issue number1-2
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Ischemic Preconditioning
Aging of materials
Exercise
Food
Reperfusion Injury
Rats
Effluents
Norepinephrine
Recovery
Liquids
Pressure

Keywords

  • Aging
  • Caloric restriction
  • Exercise training
  • Ischemic preconditioning

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart. / Abete, P.; Testa, G.; Galizia, G.; Mazzella, F.; Della Morte, D.; De Santis, D.; Calabrese, C.; Cacciatore, F.; Gargiulo, G.; Ferrara, N.; Rengo, G.; Sica, V.; Napoli, C.; Rengo, F.

In: Experimental Gerontology, Vol. 40, No. 1-2, 01.2005, p. 43-50.

Research output: Contribution to journalArticle

Abete, P. ; Testa, G. ; Galizia, G. ; Mazzella, F. ; Della Morte, D. ; De Santis, D. ; Calabrese, C. ; Cacciatore, F. ; Gargiulo, G. ; Ferrara, N. ; Rengo, G. ; Sica, V. ; Napoli, C. ; Rengo, F. / Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart. In: Experimental Gerontology. 2005 ; Vol. 40, No. 1-2. pp. 43-50.
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