Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart

P. Abete, G. Testa, G. Galizia, F. Mazzella, D. Della Morte, D. De Santis, C. Calabrese, F. Cacciatore, G. Gargiulo, N. Ferrara, G. Rengo, V. Sica, C. Napoli, F. Rengo

Research output: Contribution to journalArticlepeer-review

Abstract

Ischemic preconditioning (IP) has been proposed as an endogenous form of protection against ischemia reperfusion injury. IP, however, does not prevent post-ischemic dysfunction in the aging heart but may be partially corrected by exercise training and food restriction. We investigated the role of exercise training combined with food restriction on restoring IP in the aging heart. Effects of IP against ischemia-reperfusion injury in isolated hearts from adult (A, 6 months old), sedentary 'ad libitum' fed (SL), trained ad libitum fed (TL), sedentary food-restricted (SR), trained- and food-restricted senescent rats (TR) (24 months old) were investigated. Norepinephrine release in coronary effluent was determined by high performance liquid cromatography. IP significantly improved final recovery of percent developed pressure in hearts from A (p

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalExperimental Gerontology
Volume40
Issue number1-2
DOIs
Publication statusPublished - Jan 2005

Keywords

  • Aging
  • Caloric restriction
  • Exercise training
  • Ischemic preconditioning

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Fingerprint Dive into the research topics of 'Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart'. Together they form a unique fingerprint.

Cite this