Tap63gamma is required for the late stages of myogenesis

S. Cefalù, A. M. Lena, B. Vojtesek, A. Musarò, A. Rossi, G. Melino, E. Candi

Research output: Contribution to journalArticle

Abstract

p53 family members, p63 and p73, play a role in controlling early stage of myogenic differentiation. We demonstrated that TAp63gamma, unlike the other p53 family members, is markedly up-regulated during myogenic differentiation in murine C2C7 cell line. We also found that myotubes formation was inhibited upon TAp63gamma knock-down, as also indicated by atrophyic myotubes and reduction of myoblasts fusion index. Analysis of TAp63gamma-dependend transcripts identified several target genes involved in skeletal muscle contractility energy metabolism, myogenesis and skeletal muscle autocrine signaling. These results indicate that TAp63gamma is a late marker of myogenic differentiation and, by controlling different sub-sets of target genes, it possibly contributes to muscle growth, remodeling, functional differentiation and tissue homeostasis.

Original languageEnglish
Pages (from-to)894-901
Number of pages8
JournalCell Cycle
Volume14
Issue number6
DOIs
Publication statusPublished - Mar 15 2015

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Muscle Development
Skeletal Muscle Fibers
Skeletal Muscle
Autocrine Communication
Myoblasts
Differentiation Antigens
Energy Metabolism
Genes
Homeostasis
Cell Line
Muscles
Growth

Keywords

  • Differentiation
  • Muscle contractility
  • Myogenesis
  • P53
  • P63

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Cefalù, S., Lena, A. M., Vojtesek, B., Musarò, A., Rossi, A., Melino, G., & Candi, E. (2015). Tap63gamma is required for the late stages of myogenesis. Cell Cycle, 14(6), 894-901. https://doi.org/10.4161/15384101.2014.988021

Tap63gamma is required for the late stages of myogenesis. / Cefalù, S.; Lena, A. M.; Vojtesek, B.; Musarò, A.; Rossi, A.; Melino, G.; Candi, E.

In: Cell Cycle, Vol. 14, No. 6, 15.03.2015, p. 894-901.

Research output: Contribution to journalArticle

Cefalù, S, Lena, AM, Vojtesek, B, Musarò, A, Rossi, A, Melino, G & Candi, E 2015, 'Tap63gamma is required for the late stages of myogenesis', Cell Cycle, vol. 14, no. 6, pp. 894-901. https://doi.org/10.4161/15384101.2014.988021
Cefalù S, Lena AM, Vojtesek B, Musarò A, Rossi A, Melino G et al. Tap63gamma is required for the late stages of myogenesis. Cell Cycle. 2015 Mar 15;14(6):894-901. https://doi.org/10.4161/15384101.2014.988021
Cefalù, S. ; Lena, A. M. ; Vojtesek, B. ; Musarò, A. ; Rossi, A. ; Melino, G. ; Candi, E. / Tap63gamma is required for the late stages of myogenesis. In: Cell Cycle. 2015 ; Vol. 14, No. 6. pp. 894-901.
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AU - Melino, G.

AU - Candi, E.

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