Tap63gamma is required for the late stages of myogenesis

S. Cefalù, A. M. Lena, B. Vojtesek, A. Musarò, A. Rossi, G. Melino, E. Candi

Research output: Contribution to journalArticlepeer-review

Abstract

p53 family members, p63 and p73, play a role in controlling early stage of myogenic differentiation. We demonstrated that TAp63gamma, unlike the other p53 family members, is markedly up-regulated during myogenic differentiation in murine C2C7 cell line. We also found that myotubes formation was inhibited upon TAp63gamma knock-down, as also indicated by atrophyic myotubes and reduction of myoblasts fusion index. Analysis of TAp63gamma-dependend transcripts identified several target genes involved in skeletal muscle contractility energy metabolism, myogenesis and skeletal muscle autocrine signaling. These results indicate that TAp63gamma is a late marker of myogenic differentiation and, by controlling different sub-sets of target genes, it possibly contributes to muscle growth, remodeling, functional differentiation and tissue homeostasis.

Original languageEnglish
Pages (from-to)894-901
Number of pages8
JournalCell Cycle
Volume14
Issue number6
DOIs
Publication statusPublished - Mar 15 2015

Keywords

  • Differentiation
  • Muscle contractility
  • Myogenesis
  • P53
  • P63

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

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