TAp73 is downregulated in oocytes from women of advanced reproductive age

Maria Rosa Guglielmino, Manuela Santonocito, Marilena Vento, Marco Ragusa, Davide Barbagallo, Placido Borzì, Ida Casciano, Barbara Banelli, Ottavia Barbieri, Simonetta Astigiano, Paolo Scollo, Massimo Romani, Michele Purrello, Cinzia Di Pietro

Research output: Contribution to journalArticle

Abstract

Studies on oocyte transcriptome are important to understand the biological pathways involved in oogenesis, totipotence and early embryonic development. Moreover, genes regulating physiological pathways in gametes could represent potential candidates for reproductive disorders. In addition to oocyte specific transcription factors, also the members of the p53 family could be etiologically involved due to their biological functions. In fact, their role in the control of cell cycle, apoptosis and germ-line genome stability is well known. Female reproductive aging is one of the causes of fertility reduction and it is often associated with egg aneuploidy increase. In order to verify the potential involvement of p73 in reproductive aging, we determined its expression in single mature MII oocytes from two groups of women, younger than 35 or older than 38 y, respectively. We found that TAp73 isoforms are downregulated in oocytes from women older than 38 y. We confirmed these data in pools of mouse oocytes. TAp73 downregulation in oocytes from women of advanced reproductive age could explain both the reduction of fertility and the increase of newborns with chromosomal abnormalities.

Original languageEnglish
Pages (from-to)3253-3256
Number of pages4
JournalCell Cycle
Volume10
Issue number19
DOIs
Publication statusPublished - Oct 1 2011

Keywords

  • Aneuploidy
  • Human oocyte
  • Maternal mRNAs
  • p73
  • Reproductive aging

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

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  • Cite this

    Guglielmino, M. R., Santonocito, M., Vento, M., Ragusa, M., Barbagallo, D., Borzì, P., Casciano, I., Banelli, B., Barbieri, O., Astigiano, S., Scollo, P., Romani, M., Purrello, M., & Di Pietro, C. (2011). TAp73 is downregulated in oocytes from women of advanced reproductive age. Cell Cycle, 10(19), 3253-3256. https://doi.org/10.4161/cc.10.19.17585