TY - JOUR
T1 - TAp73 promotes anti-senescence-anabolism not proliferation
AU - Agostini, Massimiliano
AU - Niklison-Chirou, Maria Victoria
AU - Catani, Maria Valeria
AU - Knight, Richard A.
AU - Melino, Gerry
AU - Rufini, Alessandro
PY - 2014
Y1 - 2014
N2 - TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation. This assumption is based on biochemical evidence of activation of anabolic metabolism, with enhanced pentose phosphate shunt (PPP) and nucleotide biosynthesis. Here, while we confirm that TAp73 expression enhances anabolism, we also substantiate its role in inhibiting proliferation and promoting cell death. Hence, we would like to propose an alternative interpretation of the accumulating data linking p73 to cellular metabolism: we suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation.
AB - TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation. This assumption is based on biochemical evidence of activation of anabolic metabolism, with enhanced pentose phosphate shunt (PPP) and nucleotide biosynthesis. Here, while we confirm that TAp73 expression enhances anabolism, we also substantiate its role in inhibiting proliferation and promoting cell death. Hence, we would like to propose an alternative interpretation of the accumulating data linking p73 to cellular metabolism: we suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation.
KW - Aging
KW - Apotosis
KW - Cancer
KW - Metabolism
KW - P53 family
KW - p73
KW - Senescence
UR - http://www.scopus.com/inward/record.url?scp=84920271599&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920271599&partnerID=8YFLogxK
M3 - Article
C2 - 25554796
AN - SCOPUS:84920271599
VL - 6
SP - 921
EP - 930
JO - Aging
JF - Aging
SN - 1945-4589
IS - 11
ER -