TAp73 promotes anti-senescence-anabolism not proliferation

Massimiliano Agostini, Maria Victoria Niklison-Chirou, Maria Valeria Catani, Richard A. Knight, Gerry Melino, Alessandro Rufini

Research output: Contribution to journalArticle

Abstract

TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation. This assumption is based on biochemical evidence of activation of anabolic metabolism, with enhanced pentose phosphate shunt (PPP) and nucleotide biosynthesis. Here, while we confirm that TAp73 expression enhances anabolism, we also substantiate its role in inhibiting proliferation and promoting cell death. Hence, we would like to propose an alternative interpretation of the accumulating data linking p73 to cellular metabolism: we suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation.

Original languageEnglish
Pages (from-to)921-930
Number of pages10
JournalAging
Volume6
Issue number11
Publication statusPublished - 2014

Keywords

  • Aging
  • Apotosis
  • Cancer
  • Metabolism
  • P53 family
  • p73
  • Senescence

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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  • Cite this

    Agostini, M., Niklison-Chirou, M. V., Catani, M. V., Knight, R. A., Melino, G., & Rufini, A. (2014). TAp73 promotes anti-senescence-anabolism not proliferation. Aging, 6(11), 921-930.